Polymer Engineering Center, Department of Mechanical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706-1572, USA.
J Biomed Mater Res B Appl Biomater. 2010 Feb;92(2):366-76. doi: 10.1002/jbm.b.31523.
In this research, injection molding was combined with a novel material combination, supercritical fluid processing, and particulate leaching techniques to produce highly porous and interconnected structures that have the potential to act as scaffolds for tissue engineering applications. The foamed structures, molded with polylactide (PLA) and polyvinyl alcohol (PVOH) with salt as the particulate, were processed without the aid of organic solvents, which can be detrimental to tissue growth. The pore size in the scaffolds is controlled by salt particulates and interconnectivity is achieved by the co-continuous blending morphology of biodegradable PLA matrix with water-soluble PVOH. Carbon dioxide (CO(2)) at the supercritical state is used to serve as a plasticizer, thereby imparting moldability of blends even with an ultra high salt particulate content, and allows the use of low processing temperatures, which are desirable for temperature-sensitive biodegradable polymers. Interconnected pores of approximately 200 microm in diameter and porosities of approximately 75% are reported and discussed.
在这项研究中，注塑成型与一种新颖的材料组合、超临界流体加工和颗粒浸出技术相结合，制造出具有潜在用作组织工程应用支架的高度多孔和互联结构。使用盐作为颗粒的聚乳酸（PLA）和聚乙烯醇（PVOH）泡沫结构是在没有有机溶剂辅助的情况下成型的，因为有机溶剂可能对组织生长有害。支架中的孔径由盐颗粒控制，通过可生物降解的 PLA 基质与水溶性 PVOH 的共连续混合形态实现了连通性。超临界状态下的二氧化碳（CO(2)）用作增塑剂，从而赋予共混物可模塑性，即使含有超高盐颗粒含量也是如此，并且允许使用低加工温度，这对于对温度敏感的可生物降解聚合物是理想的。报告并讨论了约 200 微米直径的互联孔和约 75%的孔隙率。
