吲哚美辛对兔实验性脑膜炎病理生理学的影响。

Effect of indomethacin on the pathophysiology of experimental meningitis in rabbits.

作者信息

Tureen J H, Täuber M G, Sande M A

机构信息

Department of Pediatrics, University of California, San Francisco.

出版信息

J Infect Dis. 1991 Mar;163(3):647-9. doi: 10.1093/infdis/163.3.647.

DOI:10.1093/infdis/163.3.647

PMID:1995738

Abstract

The effects of indomethacin on central nervous system abnormalities in rabbits with experimental pneumococcal meningitis were studied. As expected, prostaglandin E2 levels in cerebrospinal fluid were significantly lower in the indomethacin-treated group, indicating that the drug effectively reduced prostaglandin synthesis. Brain edema was markedly attenuated in the indomethacin-treated group; however, cerebrospinal fluid white blood cell counts, lactate and protein concentrations, and intracisternal pressure were not significantly different between groups. It seems that indomethacin, while effective in reducing brain edema, does not significantly affect other important pathophysiologic alterations in experimental pneumococcal meningitis.

摘要

研究了吲哚美辛对实验性肺炎球菌性脑膜炎家兔中枢神经系统异常的影响。正如预期的那样，吲哚美辛治疗组脑脊液中前列腺素E2水平显著降低，表明该药物有效降低了前列腺素的合成。吲哚美辛治疗组脑水肿明显减轻；然而，两组之间脑脊液白细胞计数、乳酸和蛋白质浓度以及脑池内压力并无显著差异。吲哚美辛虽然能有效减轻脑水肿，但似乎对实验性肺炎球菌性脑膜炎的其他重要病理生理改变并无显著影响。