[CYP4F2基因单倍型与心肌梗死的关联]
[Association on the haplotypes of CYP4F2 gene and myocardial infarction].
作者信息
Huang Ding, Fu Zhen-Yan, Yang Yi-Ning, Xie Xiang, Wang Ying-Hong, Ma Yi-Tong
机构信息
The Cardiovascular Center, the First Affiliated Hospital of Xinjiang Medical University, Urumuqi, China.
出版信息
Zhonghua Liu Xing Bing Xue Za Zhi. 2009 Jul;30(7):733-6.
OBJECTIVE
The aim of this study was to assess the association between human CYP4F2 gene and myocardial infarction (MI), using a haplotype-based case-control study. A separate analysis on gender was also carried out.
METHODS
There were 250 MI patients and 250 control subjects genotyped for 5 SNPs of the human CYP4F2 gene (rs3093105, rs3093135, rs1558139, rs2108622, rs3093200). Data were assessed on 3 separate groups: the total subjects, men and women.
RESULTS
For men, G allele was significantly higher in the MI patients than in the control subjects and the overall distribution of the haplotypes was significantly different between the MI patients and the control subjects (P=0.002). Also in men, the frequency of T-C-G haplotype was significantly higher for MI patients than for control subjects (P=0.002), and the frequency of T-C-A haplotype was significantly lower for MI patients than for control subjects (P=0.003).
CONCLUSION
Data from the present results indicated that MI was associated with G allele of rs2108622 in men, suggesting that T-C-G haplotype might serve as genetic marker for MI in men.
目的
本研究旨在通过基于单倍型的病例对照研究，评估人类CYP4F2基因与心肌梗死（MI）之间的关联。同时还对性别进行了单独分析。
方法
对250例MI患者和250例对照受试者进行了人类CYP4F2基因5个单核苷酸多态性（rs3093105、rs3093135、rs1558139、rs2108622、rs3093200）的基因分型。数据在3个独立组中进行评估：总受试者、男性和女性。
结果
对于男性，MI患者中G等位基因显著高于对照受试者，并且MI患者与对照受试者之间单倍型的总体分布存在显著差异（P = 0.002）。同样在男性中，MI患者的T-C-G单倍型频率显著高于对照受试者（P = 0.002），而MI患者的T-C-A单倍型频率显著低于对照受试者（P = 0.003）。
结论
本研究结果表明，男性MI与rs2108622的G等位基因相关，提示T-C-G单倍型可能是男性MI的遗传标志物。
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