与日本男性心肌梗死相关的CYP4F2基因单倍型。
A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men.
作者信息
Fu Zhenyan, Nakayama Tomohiro, Sato Naoyuki, Izumi Yoichi, Kasamaki Yuji, Shindo Atsushi, Ohta Masakatsu, Soma Masayoshi, Aoi Noriko, Sato Mikano, Ozawa Yukio, Ma Yitong, Matsumoto Koichi, Doba Nobutaka, Hinohara Shigeaki
机构信息
Department of Advanced Medical Science, Division of Molecular Diagnostics, Nihon University School of Medicine, Tokyo, Japan.
出版信息
Mol Genet Metab. 2009 Mar;96(3):145-7. doi: 10.1016/j.ymgme.2008.11.161. Epub 2008 Dec 18.
This study assessed associations between the CYP4F2 gene and myocardial infarction (MI), using a haplotype-based case-control study of 234 MI patients and 248 controls genotyped for 5 single-nucleotide polymorphisms (rs3093105, rs3093135, rs1558139, rs2108622, rs3093200). For men, G allele frequency of rs2108622 and frequency of the T-C-G haplotype were significantly higher, and frequency of the T-C-A haplotype was significantly lower for MI patients than for controls (P=0.006, P=0.001 and P=0.002, respectively).
本研究采用基于单倍型的病例对照研究方法，对234例心肌梗死（MI）患者和248例对照者进行了5个单核苷酸多态性（rs3093105、rs3093135、rs1558139、rs2108622、rs3093200）基因分型，评估了CYP4F2基因与心肌梗死之间的关联。对于男性，MI患者rs2108622的G等位基因频率和T-C-G单倍型频率显著高于对照组，而T-C-A单倍型频率显著低于对照组（P值分别为0.006、0.001和0.002）。
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