细胞色素P450 4F2（CYP4F2）基因单核苷酸多态性与缺血性脑卒中相关。

CYP4F2 gene single nucleotide polymorphism is associated with ischemic stroke.

作者信息

Yan H-Q, Yuan Y, Zhang P, Huang Z, Chang L, Gui Y-K

机构信息

Department of Neurosurgery, PuEr Municipal Hospital, PuEr, Yunnan Province, China

Department of Neurosurgery, PuEr Municipal Hospital, PuEr, Yunnan Province, China.

出版信息

Genet Mol Res. 2015 Jan 30;14(1):659-64. doi: 10.4238/2015.January.30.8.

DOI:10.4238/2015.January.30.8

PMID:25730002

Abstract

The objective of this study was to explore the relationship between CYP4F2 gene polymorphism and ischemic stroke (IS) in the Han Chinese population. We performed a case-control study to genotype four single nucleotide polymorphisms (SNPs) (rs2108622, rs3093100, rs3093105, rs3093135) in the CYF4F2 gene. The genotype and haplotype distributions were compared between the case and control groups. We found that the GG genotype of rs2108622 in the CYP4F2 gene was associated with risk of IS (P = 0.023). Haplotype analysis indicated that the GGGT haplotype comprising rs2108622-rs3093100-rs3093105-rs3093135 was associated with IS, which suggests that the GGGT haplotype may be a risk factor for IS (P = 0.012). CYP4F2 gene polymorphism might increase the risk of IS in the Chinese population.

摘要

本研究的目的是探讨汉族人群中CYP4F2基因多态性与缺血性脑卒中（IS）之间的关系。我们进行了一项病例对照研究，对CYF4F2基因中的四个单核苷酸多态性（SNP）（rs2108622、rs3093100、rs3093105、rs3093135）进行基因分型。比较了病例组和对照组之间的基因型和单倍型分布。我们发现，CYP4F2基因中rs2108622的GG基因型与IS风险相关（P = 0.023）。单倍型分析表明，由rs2108622 - rs3093100 - rs3093105 - rs3093135组成的GGGT单倍型与IS相关，这表明GGGT单倍型可能是IS的一个风险因素（P = 0.012）。CYP4F2基因多态性可能会增加中国人群患IS的风险。