Guo Zhi-Rong, Hu Xiao-Shu, Wu Ming, Zhou Ming-Hao, Zhou Zheng-Yuan
School of Radiological Medicine and Public Health, Soochow University, Suzhou, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2009 Jun;30(6):554-8.
To discuss the risks of hypertension development with relation to the level of lipid variables among populations who had normal blood pressure at baseline study.
In April 2000, under the support of project "prevention of metabolic syndrome and multi-metabolic disorders in Jiangsu province", a cohort study was performed to obtain the baseline data among 8685 persons from age 34 to 74. In June of 2006, a follow-up investigation was carried out among those who had been in the study for 5 years after the baseline study started. 2603 persons who met the selection criteria and showed normal blood pressure during baseline study, were recruited in this investigation. The interval from the baseline to the follow-up studies was 6.38 years on average. Relationship between the risk of developing hypertension and the baseline level of lipid variables were analyzed.
Relations between baseline lipid levels and the incidence of hypertension during the follow-up was discovered. In gender and age adjusted model, the lipid variables were all associated with hypertension (trend test, P<0.01). In multivariable-adjusted model, HDL-C [aRR=0.71 (95%CI: 0.61-0.99)], non-HDL-C [aRR=1.28 (95%CI: 1.14-1.83)], TC/HDL-C ratio [aRR=1.41 (95%CI: 1.25-2.03)] and TG [aRR=1.49 (95%CI: 1.30-2.13)] were again associated with hypertension (trend test, P<0.05). Even the aRR was much weakened after the baseline SBP, DBP were adjusted with Cox model, the significant relation of hypertension to HDL-C, TC/HDL-C ratio and TG still existed. Excluding the two factors of obesity (BMI> or =28) and diabetes which had been recognized in marked linking with hypertension, lipid variables were still associated with hypertension.
Dyslipidemia might occur before being hypertensive. Hypertension was associated with HDL-C, TC/HDL-C and TG or even exclusion of obesity, diabetes and factors of smoking and drinking or baseline level of SBP, DBP were adjusted.
探讨在基线研究时血压正常的人群中，高血压发生风险与血脂变量水平之间的关系。
2000年4月，在“江苏省代谢综合征及多种代谢紊乱的预防”项目支持下，进行了一项队列研究，以获取8685名年龄在34至74岁人群的基线数据。2006年6月，对基线研究开始后已参与研究5年的人群进行了随访调查。本次调查纳入了2603名符合入选标准且在基线研究期间血压正常的人员。从基线到随访研究的平均间隔时间为6.38年。分析了高血压发生风险与血脂变量基线水平之间的关系。
发现了基线血脂水平与随访期间高血压发病率之间的关系。在性别和年龄调整模型中，血脂变量均与高血压相关（趋势检验，P<0.01）。在多变量调整模型中，高密度脂蛋白胆固醇（HDL-C）[调整后相对危险度（aRR）=0.71（95%可信区间：0.61 - 0.99）]、非高密度脂蛋白胆固醇（non-HDL-C）[aRR=1.28（95%可信区间：1.14 - 1.83）]、总胆固醇/高密度脂蛋白胆固醇比值（TC/HDL-C ratio）[aRR=1.41（95%可信区间：1.25 - 2.03）]和甘油三酯（TG）[aRR=1.49（95%可信区间：1.30 - 2.13）]再次与高血压相关（趋势检验，P<0.05）。即使在使用Cox模型对基线收缩压（SBP）、舒张压（DBP）进行调整后aRR大幅减弱，高血压与HDL-C、TC/HDL-C比值和TG之间的显著关系仍然存在。排除已被确认与高血压有明显关联的肥胖（体重指数BMI≥28）和糖尿病这两个因素后，血脂变量仍与高血压相关。
血脂异常可能在高血压发生之前出现。即使排除肥胖、糖尿病以及吸烟、饮酒因素或对基线SBP、DBP水平进行调整后，高血压仍与HDL-C、TC/HDL-C和TG相关。
