Chen Chen, Xu Yan, Guo Zhi-rong, Yang Jie, Wu Ming, Hu Xiao-shu
School of Public Health, Southeast University, Nanjing, Jiangsu 210009, China.
Lipids Health Dis. 2014 Jul 8;13:108. doi: 10.1186/1476-511X-13-108.
Visceral adiposity index (VAI), a novel sex-specific index for visceral fat measurement, has been proposed recently. We evaluate the efficacy of VAI in identifying diabetes risk in Chinese people, and compare the predictive ability between VAI and other body fatness indices, i.e., waist circumference (WC), body mass index (BMI) and waist- to- height ratio (WHtR).
Participants (n=3,461) were recruited from an ongoing cohort study in Jiangsu Province, China. Hazard ratio (HR) and corresponding 95% confidence interval (CI) between diabetes risk and different body fatness indices were evaluated by Cox proportional hazard regression model. Receiver operating characteristic (ROC) curve and area under curve (AUC) were applied to compare the ability of identifying diabetes risk between VAI, WC, WHtR and BMI.
A total number of 160 new diabetic cases occurred during the follow-up, with an incidence of 4.6%. Significant positive associations were observed for VAI with blood pressure, fasting plasma glucose, triglyceride, WC, BMI and WHtR. Moreover, increased VAI was observed to be associated with higher diabetes risk with a positive dose-response trend (p for trend<0.001). As compared to individuals with the lowest VAI, those who had the highest VAI were at 2.55-fold risk of diabetes (95% CI: 1.58-4.11). The largest AUC was observed for VAI, following by WC, WHtR and BMI.
VAI is positively associated with the risk of diabetes. Compared to other indices for body fatness measurements, VAI is a better and convenience surrogate marker for visceral adipose measurement and could be used in identifying the risk of diabetes in large-scale epidemiologic studies.
内脏脂肪指数（VAI）是一种新的用于测量内脏脂肪的性别特异性指数，最近被提出。我们评估VAI在中国人群中识别糖尿病风险的效能，并比较VAI与其他体脂指数（即腰围（WC）、体重指数（BMI）和腰高比（WHtR））之间的预测能力。
参与者（n = 3461）来自中国江苏省一项正在进行的队列研究。通过Cox比例风险回归模型评估糖尿病风险与不同体脂指数之间的风险比（HR）及相应的95%置信区间（CI）。应用受试者工作特征（ROC）曲线和曲线下面积（AUC）来比较VAI、WC、WHtR和BMI识别糖尿病风险的能力。
随访期间共发生160例新发糖尿病病例，发病率为4.6%。观察到VAI与血压、空腹血糖、甘油三酯、WC、BMI和WHtR之间存在显著正相关。此外，VAI升高与更高的糖尿病风险相关，呈正剂量反应趋势（趋势p<0.001）。与VAI最低的个体相比，VAI最高的个体患糖尿病的风险是其2.55倍（95%CI：1.58 - 4.11）。观察到VAI的AUC最大，其次是WC、WHtR和BMI。
VAI与糖尿病风险呈正相关。与其他体脂测量指数相比，VAI是一种更好且方便的内脏脂肪测量替代标志物，可用于大规模流行病学研究中识别糖尿病风险。
