Camacho J, Arnalich F, Zamorano A F, Vázquez J J
Department of Internal Medicine, La Paz Hospital, Facultad Autónoma de Medicina, Madrid, Spain.
J Intern Med. 1991 Jan;229(1):49-54. doi: 10.1111/j.1365-2796.1991.tb00305.x.
Serum erythropoietin (S-EPO) levels were measured in 50 patients with anaemia of chronic disorders (ACD), classified into three groups according to their aetiology: inflammatory (n = 20), infectious (n = 15) and neoplastic (n = 15). The inflammatory group showed a higher mean S-EPO level (mean value +/- SEM, 69 +/- 11 mU ml-1) than the neoplastic (43 +/- 5 mU ml-1; P less than 0.05) and infectious groups (27 +/- 4 mU ml-1; P less than 0.01). The S-EPO level in the inflammatory group also differed from that of 32 healthy controls (36 +/- 3 mU ml-1; P less than 0.05). Fourteen patients with added iron deficiency (12 subjects from the inflammatory group) showed the highest S-EPO concentration (72 +/- 17 mU ml-1). Conversely, S-EPO levels were lower in febrile subjects (12 patients with infection and five with malignancy) than in non-febrile patients (28 +/- 4 mU ml-1 vs. 55 +/- 7 mU ml-1; P less than 0.01). In the infectious group, the logarithm of S-EPO correlated directly with the haemoglobin and haematocrit values. We conclude that differences in S-EPO concentration in ACD may be further related to the patient's iron stores and temperature. A decrease in EPO production may contribute to the pathogenesis of ACD secondary to infection.
对50例慢性疾病性贫血（ACD）患者的血清促红细胞生成素（S-EPO）水平进行了检测，这些患者根据病因分为三组：炎症性（n = 20）、感染性（n = 15）和肿瘤性（n = 15）。炎症组的平均S-EPO水平（平均值±标准误，69±11 mU/ml）高于肿瘤组（43±5 mU/ml；P<0.05）和感染组（27±4 mU/ml；P<0.01）。炎症组的S-EPO水平也与32名健康对照者的水平不同（36±3 mU/ml；P<0.05）。14例合并缺铁的患者（炎症组12例）的S-EPO浓度最高（72±17 mU/ml）。相反，发热患者（12例感染患者和5例恶性肿瘤患者）的S-EPO水平低于非发热患者（28±4 mU/ml对55±7 mU/ml；P<0.01）。在感染组中，S-EPO的对数与血红蛋白和血细胞比容值直接相关。我们得出结论，ACD中S-EPO浓度的差异可能进一步与患者的铁储备和体温有关。促红细胞生成素产生减少可能有助于继发于感染的ACD的发病机制。
