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[阻塞性睡眠呼吸暂停低通气综合征:手术并发症及预防策略]

[Obstructive sleep apnea hypopnea syndrome: surgical complications and strategy for avoidance].

作者信息

Liu Da-Yu, Cai Xiao-Lan, Liu Hong-Ying

机构信息

Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan 250012, China.

出版信息

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Jul;44(7):555-60.

Abstract

OBJECTIVE

To analyze the surgical complications in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and discuss the risk factors and preliminary strategies for prevention of complications.

METHODS

From September 1998 to March 2007, 653 OSAHS patients confirmed by polysomnography were treated by different surgical approaches according to their obstructive sites, which included uvulopalatopharyngoplasty (UPPP) in 586 cases, nasal surgery in 104 cases/times, hyoid suspension surgery in 53 cases/times, respectively or at the same time. Local anesthesia was used in 294 cases and general anesthesia in 359 cases. Two hundreds and seventeen cases were treated by continuous positive airway pressure (CPAP) 3 to 7 days pre-operation and 2 to 3 days post-operation.

RESULTS

Perioperative complications were found in 57 OSAHS cases (93 times), the incidence of peri-operative complications was 8.7% (57/653), including respiratory problems in 19 cases/times and 1 death occurred during inducing stage in general anesthesia. Profuse bleeding was encountered in 9 cases/times during operation and primary and secondary bleeding in 27 cases/times, cardiopathy and hypertension crisis in 31 cases/times and cerebral stroke and hemiplegia in 1 case, reactive somnolence in 3 cases/times and reactive hyperglycemia in 3 cases/times. Data were analyzed by the multivariate logistic regression model. The results showed that the complications were significantly reduced after CPAP treatment during peri-operative stage and increased accompanied with patients' hypertension, choice of general anesthesia, BMI and AHI. All patients were followed-up more than 1 year. After UPPP, 23.9% cases (140/586) had sensation of foreign body in pharynx and alleviated in 6 to 12 months. Scar tissues in oropharynx in 7 cases, nasopharyngeal stenosis in 1 case, atrophy rhinitides and atrophy pharyngitis in 3 cases, nasopharyngeal un-closure and long-term nasopharyngeal reflex in 3 cases. Conclusions Peri-operative complications are more common in obese and severe OSAHS patients, especially when they accompanied with hypertension. The corresponding strategies should be taken to reduce complications in OSAHS surgery, which include controlling the hypertension effectively, performing CPAP treatment actively, cooperating with interdisciplinary doctors, monitoring closely after operation. It is important to reduce surgical sequelae through improving surgical skills and not enlarging the surgical scale blindly.

摘要

目的

分析阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的手术并发症,探讨并发症的危险因素及预防的初步策略。

方法

1998年9月至2007年3月,对653例经多导睡眠图确诊的OSAHS患者,根据其阻塞部位采用不同的手术方法,其中悬雍垂腭咽成形术(UPPP)586例,鼻腔手术104例/次,舌骨悬吊术53例/次,分别或同时进行。294例采用局部麻醉,359例采用全身麻醉。217例患者在术前3至7天及术后2至3天采用持续气道正压通气(CPAP)治疗。

结果

57例OSAHS患者(共93次)出现围手术期并发症,围手术期并发症发生率为8.7%(57/653),其中呼吸问题19例/次,全身麻醉诱导期死亡1例。术中大出血9例/次,原发性和继发性出血27例/次,心脏病和高血压危象31例/次,脑卒中和偏瘫1例,反应性嗜睡3例/次,反应性高血糖3例/次。采用多因素logistic回归模型进行数据分析。结果显示,围手术期CPAP治疗后并发症明显减少,并发症与患者高血压、全身麻醉选择、体重指数(BMI)及睡眠呼吸暂停低通气指数(AHI)有关。所有患者均随访1年以上。UPPP术后,23.9%的患者(140/586)咽部有异物感,6至12个月后缓解。口咽瘢痕组织7例,鼻咽狭窄1例,萎缩性鼻炎和咽炎3例,鼻咽未闭及长期鼻咽反射3例。结论肥胖及重度OSAHS患者围手术期并发症较常见,尤其是合并高血压时。应采取相应策略减少OSAHS手术并发症,包括有效控制高血压、积极进行CPAP治疗、多学科协作、术后密切监测。通过提高手术技巧、不盲目扩大手术范围来减少手术后遗症很重要。

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