Mehta Priyanka, Singh Kunwar Bahadur
Endocrinology Laboratory, Department of Animal Science M.J.P. Rohilkhand University, Bareilly 243 006, India.
Indian J Exp Biol. 2009 Sep;47(9):770-2.
Reserpine functions as an anti-stress agent providing relaxation to animals under stressful conditions. An attempt was made to find out functions of reserpine in unstressed albino rats and its role in steroidogenesis. The effects of the drug (25 and 35 microg, im daily for 3-5 days) were observed by recording the changes in body weights, concentration of ascorbate (liver and adrenals) and cholesterol (liver, adrenal and testes) of the animals. A dose of 25 microg reserpine 3-5 days was ineffective as there were no significant changes after the treatment. On the other hand 35 microg reserpine was found to be effective because there was significant increase in body weights, levels of ascorbate and cholesterol in respective tissues after 3-5 days administration. Therefore it is clear that in unstressed animals reserpine is stimulatory for liver but inhibitory for adrenal and testes under high doses.
利血平作为一种抗应激剂，能使处于应激状态的动物放松。本研究旨在探究利血平在未受应激的白化大鼠中的作用及其在类固醇生成中的角色。通过记录动物体重、抗坏血酸盐（肝脏和肾上腺）浓度以及胆固醇（肝脏、肾上腺和睾丸）的变化，观察了该药物（25微克和35微克，每日肌肉注射，持续3 - 5天）的作用。25微克利血平连续注射3 - 5天无效，因为治疗后无显著变化。另一方面，35微克利血平被发现是有效的，因为给药3 - 5天后，各组织中的体重、抗坏血酸盐水平和胆固醇均显著增加。因此，很明显，在未受应激的动物中，高剂量的利血平对肝脏有刺激作用，但对肾上腺和睾丸有抑制作用。
