Chinoy N J, Rao M V
Endokrinologie. 1982 Nov;80(3):287-93.
The effects of estradiol benzoate (E2B) at a dose of 50 micrograms/day/rat for 15 days were investigated on ascorbate metabolism, steroidogenesis, protein, cholesterol levels of testis, adrenal and serum testosterone, LH and FSH profiles of rats. The data revealed that E2B manifested a direct effect on testicular and probably adrenal steroidogenesis. But serum gonadotrophin levels remained unchanged. The treatment also brought about a decline in ascorbate metabolism, activities of 3 beta and 17 beta hydroxysteroid dehydrogenases and alteration in protein level concomitant with the accumulation of cholesterol in both steroidogenic organs. Estrogen treatment was more effective in adult male rats than in the immature ones.
研究了苯甲酸雌二醇（E2B）以50微克/天/大鼠的剂量持续15天，对大鼠的抗坏血酸代谢、类固醇生成、蛋白质、睾丸胆固醇水平、肾上腺和血清睾酮、促黄体生成素（LH）和促卵泡生成素（FSH）水平的影响。数据显示，E2B对睾丸以及可能对肾上腺类固醇生成有直接影响。但血清促性腺激素水平保持不变。该处理还导致抗坏血酸代谢下降、3β和17β羟类固醇脱氢酶活性降低，以及蛋白质水平改变，同时伴随着两个类固醇生成器官中胆固醇的积累。雌激素处理对成年雄性大鼠比未成熟大鼠更有效。
