Institute of Software, School of Electronics Engineering and Computer Science, Key Laboratory of High Confidence Software Technologies, Ministry of Education, Peking University, Beijing, China, 100871.
Langmuir. 2010 Feb 2;26(3):1416-9. doi: 10.1021/la903137f.
Circular DNA logic gates were constructed on the basis of DNA three-way branch migration. In this logic system, circular DNA was used as a basic work unit and linear single-strand DNA was used as input and output signals. Making use of the circular structure, most of the DNA-specific recognition regions were designed in a single DNA ring. Depending on accurate DNA sequence recognition and highly effective strand displacement, the logic gates yielded correct results. In addition, the positions of gold nanoparticles (AuNPs) were detected as an alternative approach to determine logic results. Thus, the accurate and tunable control of DNA/AuNPs may be applied widely in DNA nanotechnology.
基于 DNA 三链分支迁移构建了环形 DNA 逻辑门。在这个逻辑系统中，环形 DNA 被用作基本工作单元，线性单链 DNA 被用作输入和输出信号。利用环形结构，大多数 DNA 特异性识别区域被设计在单个 DNA 环中。通过精确的 DNA 序列识别和高效的链置换，逻辑门产生了正确的结果。此外，还可以通过检测金纳米粒子（AuNPs）的位置来作为确定逻辑结果的替代方法。因此，DNA/AuNPs 的精确和可调控制可能会广泛应用于 DNA 纳米技术。
