Ibrahim Maha, Qari Mohamad Hasan, Sait Wafa, Abulela Mansor
Hematology Department, College of Medicine, King Adulaziz University Hospital, Jeddah 21589, Saudi Arabia.
Hemoglobin. 2009;33(6):534-8. doi: 10.3109/03630260903332981.
Fetal hemoglobin (Hb F) is the normal hemoglobin (Hb) that is present in the fetus and usually almost absent in adults. The objective of this study was to assess the changes in Hb F levels during normal pregnancy. The level of Hb F was determined in serial blood samples from women at different stages of pregnancy using cation exchange high performance liquid chromatography (HPLC) and compared to age and sex-matched controls. A significant increase (p <0.001) was observed in the level of maternal Hb F; the mean Hb F level during pregnancy was 0.71 +/- 0.51%, while in the non pregnant control group it was 0.28 +/- 0.35%. There was no significant difference in Hb F levels in the three trimester groups using the ANOVA test (F = 0.25). Correlation studies between the gestational age and level of Hb F showed no significant increase of Hb F with advancing pregnancy (R = -0.053, p >0.05). The cause of the rise in Hb F is yet to be elucidated.
胎儿血红蛋白（Hb F）是胎儿体内存在的正常血红蛋白，在成年人中通常几乎不存在。本研究的目的是评估正常妊娠期间Hb F水平的变化。使用阳离子交换高效液相色谱法（HPLC）测定不同妊娠阶段女性的系列血样中的Hb F水平，并与年龄和性别匹配的对照组进行比较。观察到母体Hb F水平显著升高（p <0.001）；妊娠期间Hb F的平均水平为0.71 +/- 0.51%，而在非妊娠对照组中为0.28 +/- 0.35%。使用方差分析（F = 0.25），三个孕期组的Hb F水平无显著差异。胎龄与Hb F水平之间的相关性研究表明，随着妊娠进展，Hb F没有显著升高（R = -0.053，p >0.05）。Hb F升高的原因尚待阐明。
