Unidade de Hematologia, Serviço de Patologia Clínica do Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Clin Chem Lab Med. 2010 Feb;48(2):255-7. doi: 10.1515/CCLM.2010.035.
Automated hematological analyzers have contributed to more precise and faster results. They also make it possible to measure several blood cell parameters automatically. Among the parameters provided, platelet indices are probably the most ignored by clinical laboratories due to the difficulty of standardization, as well as being affected by a range of methodological problems. It has been suggested that each laboratory determines its own reference intervals with the equipment used.
Our goal was to determine the reference range of platelet distribution width (PDW) in venous blood samples from 231 patients using the Pentra 120 ABX hematology analyzer.
The PDW median was 13.3%, with a reference range of 10.0%-17.9% for the 5th-95th percentiles, with a confidence interval of 95%.
Among all indices, the PDW has been receiving attention due to its usefulness for distinguishing between reactive thrombocytosis and thrombocytosis associated with myeloproliferative disorder. Determination of the PDW reference range is fundamental, and the association of this parameter with the platelet number and mean platelet volume may be used for the diagnosis and differentiation of several pathologies.
自动化血液分析仪有助于提供更精确和更快的结果。它们还可以自动测量多个血细胞参数。在提供的参数中，血小板指数可能是临床实验室最容易忽略的参数之一，因为其标准化存在困难，并且受到一系列方法学问题的影响。有人建议每个实验室都使用自己的设备来确定自己的参考区间。
我们的目标是使用 Pentra 120 ABX 血液分析仪确定 231 例患者静脉血样的血小板分布宽度（PDW）参考范围。
PDW 的中位数为 13.3%，第 5-95 百分位的参考范围为 10.0%-17.9%，置信区间为 95%。
在所有指标中，PDW 因其在区分反应性血小板增多症和与骨髓增生性疾病相关的血小板增多症方面的有用性而受到关注。确定 PDW 的参考范围至关重要，该参数与血小板数量和平均血小板体积的关联可用于诊断和区分几种病理。
