Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9119, USA.
Acta Psychiatr Scand. 2010 Jun;121(6):480-4. doi: 10.1111/j.1600-0447.2009.01516.x. Epub 2009 Dec 2.
In order to evaluate the presence of treatment emergent suicidal ideation (SI), it becomes necessary to identify those patients with SI at the onset of treatment. The purpose of this report is to identify sociodemographic and clinical features that are associated with SI in major depressive disorder (MDD) patients prior to treatment with a selective serotonin reuptake inhibitor.
This multisite study enrolled 265 out-patients with non-psychotic MDD. Sociodemographic and clinical features of participants with and without SI were compared post hoc.
Social phobia, bulimia nervosa, number of past depressive episodes, and race were independently associated with SI by one or more SI measure.
Concurrent social phobia and bulimia nervosa may be potential risk factors for SI in patients with non-psychotic MDD. Additionally, patients with more than one past depressive episode may also be at increased risk of SI.
为了评估治疗中出现的自杀意念（SI），有必要在治疗开始时识别出那些有 SI 的患者。本报告的目的是确定与治疗前使用选择性 5-羟色胺再摄取抑制剂治疗的重度抑郁症（MDD）患者的 SI 相关的社会人口学和临床特征。
这项多中心研究纳入了 265 名非精神病性 MDD 的门诊患者。事后比较了有和没有 SI 的参与者的社会人口学和临床特征。
社交恐惧症、神经性贪食症、过去抑郁发作次数和种族与一个或多个 SI 测量指标独立相关。
同时患有社交恐惧症和神经性贪食症可能是非精神病性 MDD 患者 SI 的潜在危险因素。此外，过去有多次抑郁发作的患者也可能面临更高的 SI 风险。
