Ostacher Michael J, Nierenberg Andrew A, Rabideau Dustin, Reilly-Harrington Noreen A, Sylvia Louisa G, Gold Alexandra K, Shesler Leah W, Ketter Terence A, Bowden Charles L, Calabrese Joseph R, Friedman Edward S, Iosifescu Dan V, Thase Michael E, Leon Andrew C, Trivedi Madhukar H
VA Palo Alto Health Care System, Palo Alto, CA, USA; Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
J Psychiatr Res. 2015 Dec;71:126-33. doi: 10.1016/j.jpsychires.2015.10.004. Epub 2015 Oct 9.
People with bipolar disorder are at high risk of suicide, but no clinically useful scale has been validated in this population. The aim of this study was to evaluate the psychometric properties in bipolar disorder of the 7- and 12-item versions of the Concise Health Risk Tracking Self-Report (CHRT-SR), a scale measuring suicidal ideation, suicidal behavior, and associated symptoms.
The CHRT was administered to 283 symptomatic outpatients with bipolar I or II disorder who were randomized to receive lithium plus optimized personalized treatment (OPT), or OPT without lithium in a six month longitudinal comparative effectiveness trial. Participants were assessed using structured diagnostic interviews, clinician-rated assessments, and self-report questionnaires.
The internal consistency (Cronbach α) was 0.80 for the 7-item CHRT-SR and 0.90 for the 12-item CHRT-SR with a consistent factor structure, and three independent factors (current suicidal thoughts and plans, hopelessness, and perceived lack of social support) for the 7-item version. CHRT-SR scores are correlated with measures of depression, functioning, and quality of life, but not with mania scores.
The 7- and 12-item CHRT-SR both had excellent psychometric properties in a sample of symptomatic subjects with bipolar disorder. The scale is highly correlated with depression, functioning, and quality of life, but not with mania. Future research is needed to determine whether the CHRT-SR will be able to predict suicide attempts in clinical practice.
双相情感障碍患者有很高的自杀风险,但尚无经临床验证对该人群有用的量表。本研究的目的是评估简明健康风险追踪自我报告(CHRT-SR)7项版和12项版在双相情感障碍中的心理测量特性,该量表用于测量自杀意念、自杀行为及相关症状。
在一项为期6个月的纵向比较疗效试验中,对283名有症状的双相I型或II型障碍门诊患者施用CHRT,这些患者被随机分配接受锂盐加优化的个性化治疗(OPT),或不使用锂盐的OPT。使用结构化诊断访谈、临床医生评定评估和自我报告问卷对参与者进行评估。
7项CHRT-SR的内部一致性(Cronbach α)为0.80,12项CHRT-SR的内部一致性为0.90,具有一致的因子结构,7项版有三个独立因子(当前自杀想法和计划、绝望感以及感知到的社会支持缺乏)。CHRT-SR得分与抑郁、功能和生活质量的测量指标相关,但与躁狂得分无关。
在有症状的双相情感障碍受试者样本中,7项和12项CHRT-SR均具有出色的心理测量特性。该量表与抑郁、功能和生活质量高度相关,但与躁狂无关。未来需要开展研究以确定CHRT-SR在临床实践中是否能够预测自杀未遂。