Division of Nephrology, Department of Internal Medicine, School of Medicine, Mersin University, Mersin, Turkey.
Artif Organs. 2009 Dec;33(12):1086-90. doi: 10.1111/j.1525-1594.2009.00823.x. Epub 2009 Dec 1.
The etiology of posttransplant erythrocytosis (PTE) remains unclear, and the most frequently suggested causative factors are still a matter of controversy. We aimed to investigate serum-soluble stem cell factor (sSCF) along with serum erythropoietin (EPO) levels in renal transplant recipients (RTRs) with PTE. Thirteen RTRs with PTE, 42 RTRs without PTE, and 42 healthy controls were included. Serum sSCF and EPO levels were determined using an enzyme-linked immunosorbent assay kit. Expected and observed/expected EPO levels were calculated. Serum sSCF levels and observed/expected EPO were significantly higher in RTRs with PTE than both RTRs without PTE and controls. In RTRs with PTE, sSCF level was significantly correlated with hematocrit and observed/expected EPO, respectively. Significant correlation was also observed between hematocrit level and observed/expected EPO in RTRs with PTE. Increased sSCF level and inadequate suppression of EPO production seem to have a role in the pathogenesis of PTE.
移植后红细胞增多症（PTE）的病因仍不清楚，最常被提出的致病因素仍存在争议。我们旨在研究患有 PTE 的肾移植受者（RTR）的血清可溶性干细胞因子（sSCF）和血清促红细胞生成素（EPO）水平。纳入了 13 名患有 PTE 的 RTR、42 名无 PTE 的 RTR 和 42 名健康对照者。使用酶联免疫吸附试验试剂盒测定血清 sSCF 和 EPO 水平。计算了预期和观察到的/预期的 EPO 水平。与无 PTE 的 RTR 和对照组相比，患有 PTE 的 RTR 的血清 sSCF 水平和观察到的/预期的 EPO 明显更高。在患有 PTE 的 RTR 中，sSCF 水平与红细胞压积和观察到的/预期的 EPO 分别呈显著相关。在患有 PTE 的 RTR 中，红细胞压积水平与观察到的/预期的 EPO 之间也存在显著相关性。sSCF 水平升高和 EPO 产生抑制不足似乎在 PTE 的发病机制中起作用。
