Division of Evidence-based Medicine, Klinik für Dermatologie, Charité Universitätsmedizin, Berlin, Deutschland.
J Cosmet Dermatol. 2009 Dec;8(4):317-23. doi: 10.1111/j.1473-2165.2009.00462.x.
Hyaluronic acid (HA) preparations are the most commonly used injectable fillers in esthetic medicine. In contrast to other injectable fillers with hyaluronidase, there is a tool available to reduce unwanted depots of this filler.
The aim of this paper is to give an overview on the present literature and in addition to give some recommendations for use based on the experience of the authors.
The overview is based on a literature search.
There is some evidence from two smaller clinical trials that hyaluronidase will effectively decrease injected depots of HA. It has further been shown from case series and case reports that this reduction is clinically relevant. There is less evidence that hyaluronidase is also helpful in adverse reactions to HA-based fillers.
The reports suggest that the treatment is safe. However, adverse reactions to hyaluronidase such as allergic reactions have been reported. Patient should be informed about that before treatment.
透明质酸（HA）制剂是美容医学中最常用的注射用填充剂。与其他含有透明质酸酶的可注射填充剂相比，有一种工具可用于减少这种填充剂的不必要沉积。
本文旨在概述现有文献，并根据作者的经验提供一些使用建议。
综述基于文献检索。
有两项较小的临床试验的证据表明，透明质酸酶可有效减少注射的 HA 沉积。进一步的病例系列和病例报告表明，这种减少在临床上是有意义的。证据较少表明透明质酸酶对基于 HA 的填充剂的不良反应也有帮助。
报告表明该治疗是安全的。然而，已有报道称透明质酸酶会引起不良反应，如过敏反应。在治疗前应告知患者这一点。
