Andre Pierre, Fléchet Marie Laure
Paris Université Laser Skin Clinic, Paris, France.
J Cosmet Dermatol. 2008 Jun;7(2):136-8. doi: 10.1111/j.1473-2165.2008.00377.x.
Hyaluronic acid injections are becoming popular in aesthetic dermatology, and, sometimes, misplacements and very rarely adverse events have been reported. Hyaluronidase, an enzyme that hydrolyzes hyaluronic acid, is used to treat overcorrection or granulomatous reactions. Allergic reactions are well known except for how frequent they occur.
This paper aims to confirm the efficacy of hyaluronidase injections to dissolve hyaluronic acid, but insists on the risk of hypersensitivity with animal-derived products.
A case of angioedema due to ovine hyaluronidase is reported, and treatment is discussed.
Hyaluronidase is highly effective, but skin test must be done before injection to avoid risk of angioedema and/or Quincke's edema.
透明质酸注射在美容皮肤科越来越受欢迎，有时会有注射位置不当的情况报告，且极少出现不良事件。透明质酸酶是一种可水解透明质酸的酶，用于治疗过度矫正或肉芽肿反应。除了其发生频率外，过敏反应是广为人知的。
本文旨在证实注射透明质酸酶溶解透明质酸的疗效，但强调使用动物源性产品存在超敏反应风险。
报告1例因绵羊透明质酸酶导致血管性水肿的病例并讨论其治疗方法。
透明质酸酶非常有效，但注射前必须进行皮肤试验，以避免血管性水肿和/或昆克水肿的风险。
