Department of Plastic and Reconstructive Surgery, Korea University Medical Center, Korea University Ansan Hospital, Gyeonggi-Do, Republic of Korea.
J Plast Reconstr Aesthet Surg. 2011 Dec;64(12):1590-5. doi: 10.1016/j.bjps.2011.07.013. Epub 2011 Jul 31.
Skin necrosis following the inadvertent arterial injection of hyaluronic acid (HA) is a serious complication. It is not clear whether or not subcutaneous injections of hyaluronidase decrease skin necrosis in HA-induced vascular complications. We had four cases of HA-induced vascular complications, two of which were treated with hyaluronidase the next day. All of the patients had skin necrosis and scarring. We performed an animal study with rabbit ears in which HA filler was injected into the auricular arteries of both ears. Five rabbits each received a subcutaneous injection of 750 IU of hyaluronidase 4 and 24 h after the filler injection. The hyaluronidase-treated ears in the 4-h intervention group had significantly smaller necrotic areas (p<0.05), while the 24-h intervention group had no differences in the area of necrosis. Hyaluronidase reduced the vascular complications of HA fillers when used early, but there was no benefit to hyaluronidase injection after 24 h.
皮肤坏死是透明质酸（HA）注射入动脉后出现的一种严重并发症。目前尚不清楚透明质酸酶的皮下注射是否会减少 HA 引起的血管并发症中的皮肤坏死。我们有 4 例 HA 引起的血管并发症，其中 2 例在第二天接受了透明质酸酶治疗。所有患者均出现皮肤坏死和瘢痕形成。我们进行了一项兔耳动物研究，在兔耳的耳动脉内注射 HA 填充物。每只兔子在注射填充物后 4 和 24 小时分别接受 750 IU 的透明质酸酶皮下注射。在 4 小时干预组中，接受透明质酸酶治疗的耳朵的坏死面积明显较小（p<0.05），而 24 小时干预组的坏死面积没有差异。早期使用透明质酸酶可减少 HA 填充物的血管并发症，但在 24 小时后注射透明质酸酶没有益处。
