Chen Su-Fang, Zhu Cui-Ming, Wan Yan-Ping
Institute of Pathogenic Biology,University of South China, Hengyang, Hunan, 421001,P. R. China.
Ai Zheng. 2009 Dec;28(12):1333-6. doi: 10.5732/cjc.009.10168.
As a highly conserved nuclear protein, death domain-associated protein(Daxx) plays an important role in transcriptional control, carcinogenesis, resistance to virus infection, and so on. Daxx can be localized in promyleocytic leukaemia protein oncogenic domains, nucleoplasm, nucleolus, cytoplasm, and heterochromatin. The subcellular localization of Daxx can be changed by modification or interacting with other proteins. Under cellular stress, Daxx can interact with many kinds of molecules, and thus affect its downstream signaling pathway. The purpose of this review was to discuss Daxx's subcellular localization in different conditions and its translocation between subcellular compartments.
作为一种高度保守的核蛋白，死亡结构域相关蛋白（Daxx）在转录调控、致癌作用、抗病毒感染等方面发挥着重要作用。Daxx可定位于早幼粒细胞白血病蛋白致癌结构域、核质、核仁、细胞质和异染色质中。Daxx的亚细胞定位可通过修饰或与其他蛋白质相互作用而发生改变。在细胞应激状态下，Daxx可与多种分子相互作用，进而影响其下游信号通路。本综述的目的是探讨Daxx在不同条件下的亚细胞定位及其在亚细胞区室之间的转运。
