Chen Ya-Ning, Gu Yan
Department of General Surgery, Shanghai Ninth People's Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai, 200011,P. R. China.
Ai Zheng. 2009 Dec;28(12):1337-43. doi: 10.5732/cjc.009.10070.
Breast carcinoma is the most common malignant tumor in women. For these patients, lymph node metastasis is one of the most important prognostic factors. Recent studies suggest that lymphangiogenesis can contribute to the lymphatic metastasis in tumors. Several members of vascular endothelial growth factor (VEGF) family, such as VEGF-C, VEGF-D, and VEGF receptor-3 (VEGFR-3), have been found to promote lymphangiogenesis in breast cancer. However, there are still some controversy about the prognostic value of VEGF-D and the relation between VEGFR-3 and lymphangiogenesis. This article tried to provide an overview of the research progress of lymphangiogenic factor VEGF-D and its receptor VEGFR-3 in lymphatic metastasis of breast cancer.
乳腺癌是女性最常见的恶性肿瘤。对于这些患者，淋巴结转移是最重要的预后因素之一。最近的研究表明，淋巴管生成可促进肿瘤的淋巴转移。血管内皮生长因子（VEGF）家族的几个成员，如VEGF-C、VEGF-D和VEGF受体-3（VEGFR-3），已被发现可促进乳腺癌中的淋巴管生成。然而，关于VEGF-D的预后价值以及VEGFR-3与淋巴管生成之间的关系仍存在一些争议。本文试图概述淋巴管生成因子VEGF-D及其受体VEGFR-3在乳腺癌淋巴转移中的研究进展。
