Department of Pediatrics, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, United States.
Semin Cell Dev Biol. 2010 Feb;21(1):55-65. doi: 10.1016/j.semcdb.2009.11.018. Epub 2009 Dec 1.
SPARC is a matricellular glycoprotein that mediates interactions between cells and their microenvironment. It is produced at sites of tissue remodeling, where it regulates matrix deposition and turnover, cell adhesion, and signaling by extracellular factors, exerting profound effects on tissue architecture and cell physiology. During extensive matrix remodeling in neoplastic progression, SPARC is expressed in cancer-associated stroma and in malignant cells of some types, affecting tumor development, invasion, metastases, angiogenesis and inflammation. SPARC-induced changes in the tumor microenvironment can suppress or promote progression of different cancers depending on the tissue and cell type. Understanding the mechanism of matrix remodeling and its regulation by SPARC is essential for the development of new treatment strategies for highly aggressive cancers.
富含半胱氨酸的酸性分泌蛋白（SPARC）是一种基质细胞糖蛋白，可介导细胞与其微环境之间的相互作用。它在组织重塑部位产生，调节基质的沉积和周转、细胞黏附以及细胞外因子的信号转导，对组织结构和细胞生理学有深远影响。在肿瘤进展的广泛基质重塑过程中，SPARC 在癌相关基质和某些类型的恶性细胞中表达，影响肿瘤的发生、浸润、转移、血管生成和炎症。SPARC 诱导的肿瘤微环境变化可根据组织和细胞类型抑制或促进不同癌症的进展。了解基质重塑的机制及其受 SPARC 的调控对于开发针对高度侵袭性癌症的新治疗策略至关重要。
