Department of Pediatric Surgery, University of Texas Medical School at Houston, Houston, Texas 77030, USA.
J Surg Res. 2011 Mar;166(1):120-30. doi: 10.1016/j.jss.2009.09.010. Epub 2009 Sep 29.
High volume resuscitation and damage control surgical methods, while responsible for significantly decreasing morbidity and mortality from traumatic injuries, are associated with pathophysiologic derangements that lead to subsequent end organ edema and dysfunction. Alterations in hydrostatic and oncotic pressures frequently result in intestinal edema and subsequent dysfunction. The purpose of this review is to examine the principles involved in the development of intestinal edema, current and historical models for the study of edema, effects of edema on intestinal function (particularly ileus), molecular mediators governing edema-induced dysfunction, potential role of mechanotransduction , and therapeutic effects of hypertonic saline. We review the current state of the science as it relates to resuscitation induced intestinal edema and resultant dysfunction.
大量复苏和损伤控制性手术方法虽然显著降低了创伤性损伤的发病率和死亡率，但与导致随后的终末器官水肿和功能障碍的病理生理紊乱有关。静水压力和胶体渗透压的改变常导致肠水肿和随后的功能障碍。本综述的目的是研究肠水肿发展的原理，目前和历史上用于研究水肿的模型，水肿对肠功能的影响（特别是肠梗阻），调节水肿诱导功能障碍的分子介质，机械转导的潜在作用，以及高渗盐水的治疗效果。我们回顾了与复苏引起的肠水肿和由此产生的功能障碍相关的科学现状。
