Service d'Hématologie-Immunologie-Cytogénétique, Centre Hospitalier, Valenciennes, France.
Leuk Res. 2010 May;34(5):580-4. doi: 10.1016/j.leukres.2009.11.003. Epub 2009 Dec 2.
Small lymphocytic lymphoma (SLL) and chronic lymphocytic leukemia (CLL) are considered as similar entity by the WHO classification. We assessed the distribution of the four prognostic cytogenetic markers (deletion 11q23, 13q14, 17p13 and trisomy 12) and VH mutational status in 32 SLL and 119 CLL. Trisomy 12 was most frequent (36% vs 13%, p=0.014) and 13q14 deletion was less frequent (9% vs 44%, p=0.001) in SLL in comparison with CLL. An over representation of VH3-21 gene usage was found in SLL (17% vs 1%, p=0.011). In conclusion, SLL show specific genetic markers that distinguish them from classical CLL.
小淋巴细胞淋巴瘤（SLL）和慢性淋巴细胞白血病（CLL）在世界卫生组织分类中被视为相似实体。我们评估了 32 例 SLL 和 119 例 CLL 中四种预后细胞遗传学标记（11q23 缺失、13q14 缺失、17p13 缺失和 12 三体）和 VH 突变状态的分布。与 CLL 相比，SLL 中 12 三体最为常见（36% vs 13%，p=0.014），13q14 缺失较少见（9% vs 44%，p=0.001）。在 SLL 中发现 VH3-21 基因使用过度表达（17% vs 1%，p=0.011）。总之，SLL 具有特定的遗传标记，可将其与经典的 CLL 区分开来。
