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Cold agglutinin-associated B-cell lymphoproliferative disease shows highly recurrent gains of chromosome 3 and 12 or 18.

作者信息

Małecka Agnieszka, Delabie Jan, Østlie Ingunn, Tierens Anne, Randen Ulla, Berentsen Sigbjørn, Tjønnfjord Geir E, Trøen Gunhild

机构信息

Department of Haematology and.

Department of Pathology, Oslo University Hospital, Oslo, Norway.

出版信息

Blood Adv. 2020 Mar 24;4(6):993-996. doi: 10.1182/bloodadvances.2020001608.

DOI:10.1182/bloodadvances.2020001608
PMID:32168377
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7094025/
Abstract
摘要

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1
Cold agglutinin-associated B-cell lymphoproliferative disease shows highly recurrent gains of chromosome 3 and 12 or 18.冷凝集素相关B细胞淋巴增殖性疾病表现出3号、12号或18号染色体高度频发的增益。
Blood Adv. 2020 Mar 24;4(6):993-996. doi: 10.1182/bloodadvances.2020001608.
2
Trisomy 3 is a consistent chromosome change in malignant lymphoproliferative disorders preceded by cold agglutinin disease.
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3
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4
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Cytogenetic analysis of B-cell chronic lymphoproliferative disorders: new technology, complexities and promises.
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Translocation t(2;7)(p11;q21) associated with the CDK6/IGK rearrangement is a rare but recurrent abnormality in B-cell lymphoproliferative malignancies.与CDK6/IGK重排相关的易位t(2;7)(p11;q21)是B细胞淋巴增殖性恶性肿瘤中一种罕见但反复出现的异常情况。
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Etiologic aspects of cold agglutinin disease: evidence for cytogenetically defined clones of lymphoid cells and the demonstration that an anti-Pr cold autoantibody is derived from a chromosomally aberrant B cell clone.冷凝集素病的病因学方面：淋巴细胞细胞遗传学定义克隆的证据以及抗-Pr 冷自身抗体源自染色体异常 B 细胞克隆的证明。
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[Recent progress in the diagnosis and treatment of cold agglutinin disease].[冷凝集素病的诊断与治疗新进展]
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本文引用的文献

1
Venetoclax, bendamustine, and rituximab in patients with relapsed or refractory NHL: a phase Ib dose-finding study.维奈托克、苯达莫司汀和利妥昔单抗治疗复发或难治性 NHL 患者：一项 Ib 期剂量探索研究。
Ann Oncol. 2018 Sep 1;29(9):1932-1938. doi: 10.1093/annonc/mdy256.
2
Morphological, immunophenotypic, and genetic features of chronic lymphocytic leukemia with trisomy 12: a comprehensive review.伴有 12 三体的慢性淋巴细胞白血病的形态学、免疫表型和遗传学特征：全面综述。
Haematologica. 2018 Jun;103(6):931-938. doi: 10.3324/haematol.2017.186684. Epub 2018 May 10.
3
Recent advances in understanding the biology of marginal zone lymphoma.边缘区淋巴瘤生物学认识的最新进展
F1000Res. 2018 Mar 28;7:406. doi: 10.12688/f1000research.13826.1. eCollection 2018.
4
How I manage patients with cold agglutinin disease.冷抗体自身免疫性溶血性贫血的诊治策略
Br J Haematol. 2018 May;181(3):320-330. doi: 10.1111/bjh.15109. Epub 2018 Jan 24.
5
Frequent somatic mutations of KMT2D (MLL2) and CARD11 genes in primary cold agglutinin disease.原发性冷凝集素病中KMT2D（MLL2）和CARD11基因的频繁体细胞突变。
Br J Haematol. 2018 Dec;183(5):838-842. doi: 10.1111/bjh.15063. Epub 2017 Dec 19.
6
Targeting BCL-2 in B-cell lymphomas.靶向治疗 B 细胞淋巴瘤中的 BCL-2。
Blood. 2017 Aug 31;130(9):1081-1088. doi: 10.1182/blood-2017-04-737338. Epub 2017 Jul 19.
7
Bendamustine plus rituximab for chronic cold agglutinin disease: results of a Nordic prospective multicenter trial.苯达莫司汀联合利妥昔单抗治疗慢性冷凝集素病：一项北欧前瞻性多中心试验的结果。
Blood. 2017 Jul 27;130(4):537-541. doi: 10.1182/blood-2017-04-778175. Epub 2017 May 22.
8
Immunoglobulin heavy and light chain gene features are correlated with primary cold agglutinin disease onset and activity.免疫球蛋白重链和轻链基因特征与原发性冷凝集素病的发病及活动相关。
Haematologica. 2016 Sep;101(9):e361-4. doi: 10.3324/haematol.2016.146126. Epub 2016 May 19.
9
Cold agglutinin-mediated autoimmune hemolytic anemia.冷凝集素介导的自身免疫性溶血性贫血
Hematol Oncol Clin North Am. 2015 Jun;29(3):455-71. doi: 10.1016/j.hoc.2015.01.002. Epub 2015 Mar 12.
10
Genetic lesions in diffuse large B-cell lymphomas.弥漫性大B细胞淋巴瘤中的基因损伤
Ann Oncol. 2015 Jun;26(6):1069-1080. doi: 10.1093/annonc/mdv019. Epub 2015 Jan 20.