LENITEM - Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy.
Aging Clin Exp Res. 2009 Aug-Oct;21(4-5):266-76. doi: 10.1007/BF03324915.
To describe the clinical and neuropsychological features of a large group of cognitively intact persons subjected to brain high-resolution magnetic resonance (MR), to compare them with the general population, and to set norms for medial temporal atrophy and white matter lesions.
Participants in the Italian Brain Normative Archive (IBNA) study were 483 consecutive volunteers undergoing MR for reasons unrelated to cognition (migraine or headache, visual and balance or auditory disturbances, paresthesias, and others) and showing no brain damage. Manual tracing of hippocampal and amygdalar volumes and visual rating of white matter lesions were made. The whole study group was stratified by age (</=60 and 60+ yrs) and by the reason for MR prescription.
In the whole group, mean age and education were 52.4+/-13.7 and 9.8+/-4.2 years, respectively, and the prevalence of women was 63%. Clinical, neuropsychological and morphometric features were similar in the stratified subgroups. Neuropsychological features were those expected for age and education based on Italian normative values. Hippocampal and amygdalar volumes were not associated with age, except for the right amygdala (B -0.159, 95% CI -0.28 to -0.03, p=0.016).
Persons in the IBNA study had clinical and neuropsychological features consistent with that of the general population. Their brain morphometric features may be used as normative references for patients with suspected neurodegenerative disorders.
描述一组认知正常的个体进行脑部高分辨率磁共振（MR）检查的临床和神经心理学特征，将其与普通人群进行比较，并为内侧颞叶萎缩和白质病变制定标准。
意大利脑正常档案（IBNA）研究的参与者为 483 名连续志愿者，他们因与认知无关的原因（偏头痛或头痛、视觉和平衡或听觉障碍、感觉异常等）接受 MR 检查，且没有脑损伤。对海马体和杏仁核体积进行手动追踪，并对白质病变进行视觉评分。根据年龄（<=60 岁和 60 岁以上）和 MR 检查的原因，对整个研究组进行分层。
在整个组中，平均年龄和受教育程度分别为 52.4+/-13.7 岁和 9.8+/-4.2 年，女性患病率为 63%。在分层亚组中，临床、神经心理学和形态计量学特征相似。神经心理学特征与意大利正常参考值相符，与年龄和教育程度相关。除右侧杏仁核（B -0.159，95%CI -0.28 至 -0.03，p=0.016）外，海马体和杏仁核体积与年龄无关。
IBNA 研究中的个体具有与普通人群一致的临床和神经心理学特征。他们的大脑形态学特征可作为疑似神经退行性疾病患者的参考标准。
