School of Interdisciplinary Bioscience and Bioengineering and Department of Mechanical Engineering, Pohang University of Science and Technology, Hyoja-dong, Nam-Gu, Pohang, Gyeongbuk, Korea.
Curr Top Microbiol Immunol. 2010;340:25-50. doi: 10.1007/978-3-642-03858-7_2.
The cell-biology of intercellular communication between T cells and their partners has been greatly advanced over the past 10 years. The key morphological and motility features of cell contact-based communication between T cells and APCs can now be seen as a collection of patterns for cell-cell interactions amongst immune cells more generally, each serving to contribute to the outcome of the contact both locally and globally. Here we review the conservation of these patterns, amongst which is the emergent "immunological synapse," and describe a newly defined example, formed between the adjacent activating T cells. We subsequently seek to put these and the pattern more generally into the framework of system-wide behavior of the immune system. We postulate that the patterns are fine-tuned to provide quorum-like decisions by collections of activating and activated cells that interact over time and space.
过去 10 年来，T 细胞与其伙伴之间细胞间通讯的细胞生物学有了很大的进展。T 细胞与 APC 之间基于细胞接触的通讯的关键形态和运动特征，现在可以看作是更普遍的免疫细胞之间细胞-细胞相互作用的一系列模式，这些模式都有助于局部和全局接触的结果。在这里，我们回顾了这些模式的保守性，其中包括新兴的“免疫突触”，并描述了一个新定义的例子，它形成于相邻的激活 T 细胞之间。随后，我们试图将这些模式以及更普遍的模式纳入免疫系统的整体系统行为框架。我们假设，这些模式经过了微调，可以为随着时间和空间相互作用的激活和激活细胞的集合提供类群决策。
