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[体型与精神分裂症。一项病例对照研究]

[Somatotype and schizophrenia. A case-control study].

作者信息

Pailhez G, Rodríguez A, Ariza J, Palomo A L, Bulbena A

机构信息

Institut d'Atenció Psiquiátrica: Salut Mental i Toxicomanies, Hospital del Mar (IMAS), Unidad Docente Universidad Autónoma de Barcelona (UDIMAS).

出版信息

Actas Esp Psiquiatr. 2009 Sep-Oct;37(5):258-66.

Abstract

AIMS

To compare somatotypes of schizophrenic patients and healthy controls and to examine some associations between somatic (joint mobility, somatotype) and psychopathological (anxiety, clinical seriousness and schizophrenic types) features.

METHODS

Thirty four in-patients with DSM-IV diagnosis of schizophrenia assessed by SCID-I, aged 18 to 50 years, were recruited as cases. Thirty two subjects of a general non-clinical population were recruited as controls. Heath-Carter method and 5 questions to detect joint hypermobility were used to assess both somatotype and joint hypermobility. Trait anxiety (STAI) and BPRS were assessed at medical discharge.

RESULTS

There were no statistically significant differences between mean somatotype groups (cases: 4(1/2) 5(1/2) 1(1/2); controls: 5 - 5 - 1(1/2)). Schizophrenic patients showed significantly more divergence among themselves in relationship to their own common mean [t = 1.98; gl = 64; p = 0.05] and accounted for more ectomorphic categories than the control group. Somatotype means of paranoid and disorganized types were significantly more homogeneous (with greater values of ectomorphism) than undifferentiated type [X2 = 6.61; gl = 2; p = 0.037]. There was a tendency towards positive association between anxiety - joint hypermobility and anxiety- ectomorphism, but it did not reach a statistically significant level.

CONCLUSIONS

In spite of their limitations, the results provide suggestive data for identification of subtypes in mental illnesses that can be used as a nosologic knowledge or as potential risk markers.

摘要

目的

比较精神分裂症患者与健康对照者的体型,并研究躯体特征(关节活动度、体型)与精神病理学特征(焦虑、临床严重程度及精神分裂症类型)之间的一些关联。

方法

招募34名年龄在18至50岁之间、经SCID-I评估为DSM-IV诊断的精神分裂症住院患者作为病例组。招募32名普通非临床人群作为对照组。采用希思-卡特法和5个用于检测关节过度活动的问题来评估体型和关节过度活动。在出院时评估特质焦虑(STAI)和简明精神病评定量表(BPRS)。

结果

体型均值组之间无统计学显著差异(病例组:4(1/2) 5(1/2) 1(1/2);对照组:5 - 5 - 1(1/2))。精神分裂症患者自身与共同均值之间的差异显著更大[t = 1.98;自由度 = 64;p = 0.05],且外胚层体型分类比对照组更多。偏执型和紊乱型的体型均值比未分化型显著更一致(外胚层体型值更高)[X2 = 6.61;自由度 = 2;p = 0.037]。焦虑与关节过度活动以及焦虑与外胚层体型之间存在正相关趋势,但未达到统计学显著水平。

结论

尽管存在局限性,但研究结果为识别精神疾病亚型提供了提示性数据,这些数据可作为疾病分类学知识或潜在风险标志物。

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