Department of Applied Life Science, Kon Kuk University, Seoul, 143-701, South Korea.
Phytother Res. 2010 Mar;24(3):469-71. doi: 10.1002/ptr.3056.
The methanolic extract of the rhizomes parts of Agelica purpuraefolia was investigated for its activity against chloroquine-sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method. Two natural khellactone, (+)-4'-Decanoyl-cis-khellactone (1) and (+)-3'-Decanoyl-cis-khellactone (2) were isolated from the rhizomes parts of A. purpuraefolia. Two compounds were evaluated for in vitro antiplasmodial activities as well as their cytotoxic potential on SK-OV-3 cancer cell line cells. Compounds 1, 2 showed notable growth inhibitory activity against chloroquine-sensitive strains of Plasmodium falciparum with IC(50) values from 1.5 and 2.4 microM. This compound showed no significant cytotoxicity (IC(50) > 100 microM) evaluated using SK-OV-3 cancer cell line cells. This is the first report on the antiplasmodial activity of the compounds from A. purpuraefolia.
紫茎泽兰根部分的甲醇提取物，通过寄生虫乳酸脱氢酶试验方法，研究其对氯喹敏感株恶性疟原虫的活性。从紫茎泽兰的根部分离得到两种天然的对映贝壳杉烯酮，（+）-4′-癸酰基-顺式贝壳杉烯酮（1）和（+）-3′-癸酰基-顺式贝壳杉烯酮（2）。两种化合物被评估了体外抗疟原虫活性以及对 SK-OV-3 癌细胞的细胞毒性。化合物 1、2 对氯喹敏感株恶性疟原虫表现出显著的生长抑制活性，IC（50）值为 1.5 和 2.4μM。使用 SK-OV-3 癌细胞系细胞，该化合物没有显示出明显的细胞毒性（IC（50）>100μM）。这是首次报道来自紫茎泽兰的化合物的抗疟原虫活性。
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