Department of Applied Life Science, Kon Kuk University, Seoul 143-701, South Korea.
Phytother Res. 2009 Nov;23(11):1634-7. doi: 10.1002/ptr.2838.
Dendropanax morbifera Leveille (Araliaceae) is well known in Korea traditional medicine for a variety of diseases. The methanol extract of the lower stem parts of D. morbifera was investigated for its activity against chloroquine-sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method. Two cycloartane-type glycosides oleifoliosides A (1) and B (2), and dendropanoxide (3), beta-amyrin (4), alpha-amyrin (5) have been isolated from the stem parts of D. morbifera. All five compounds were evaluated for in vitro antiplasmodial activities as well as their cytotoxic potential on SK-OV-3 cancer cell lines. Compounds 2 and 3 showed notable growth inhibitory activity against chloroquine-sensitive strains of Plasmodium falciparum with IC(50) values of 6.2 and 5.3 microm. This compound showed no significant cytotoxicity (IC(50) > 150 microm) evaluated using SK-OV-3 cancer cell lines. This is the first report on the antiplasmodial activity of the compounds from D. morbifera.
五加科树参（Dendropanax morbifera Leveille）在韩国传统医学中因其对多种疾病的疗效而广为人知。采用寄生虫乳酸脱氢酶检测法，研究了树参下部茎部分的甲醇提取物对氯喹敏感株疟原虫的活性。从树参的茎部分离出两种环阿尔泰型糖苷 Oleifoliosides A（1）和 B（2），以及 dendropanoxide（3）、β-香树脂醇（4）、α-香树脂醇（5）。评估了这五种化合物的体外抗疟活性及其对 SK-OV-3 癌细胞系的细胞毒性。化合物 2 和 3 对氯喹敏感株疟原虫表现出显著的生长抑制活性，IC50 值分别为 6.2 和 5.3μm。该化合物对 SK-OV-3 癌细胞系的细胞毒性没有明显影响（IC50>150μm）。这是首次报道树参中化合物的抗疟活性。
