Tulane University Health Sciences Center, New Orleans, LA 70112, USA.
J Trauma Stress. 2009 Dec;22(6):534-9. doi: 10.1002/jts.20475.
Population-based association studies have supported the heritability of posttraumatic stress disorder (PTSD). This study explored the influence of genetic variation in the dopamine transporter (DAT) 3' untranslated region variable number tandem repeat on the development of PTSD in preschool children exposed to Hurricane Katrina, diagnosed using a developmentally appropriate semistructured interview. A diagnosis according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition , (DSM-IV; American Psychiatric Association, 1994), total symptoms, and specifically Criterion D symptoms were significantly more likely to be found in children with the 9 allele. This study replicates a previous finding in adults with PTSD. The specificity of this finding to the increased arousal symptoms of Criterion D suggests that dopamine and the DAT allele may contribute to one heritable path in a multifinality model of the development of PTSD.
基于人群的关联研究支持创伤后应激障碍（PTSD）的遗传性。本研究探讨了多巴胺转运体（DAT）3'非翻译区可变数串联重复的遗传变异对暴露于卡特里娜飓风的学龄前儿童 PTSD 发展的影响，这些儿童通过发展适当的半结构化访谈进行诊断。根据《精神障碍诊断与统计手册》第四版（DSM-IV；美国精神病学协会，1994 年）进行诊断，总症状，特别是标准 D 症状，在携带 9 等位基因的儿童中更有可能出现。本研究复制了先前在 PTSD 成人中的发现。这一发现的特异性表明，多巴胺和 DAT 等位基因可能有助于 PTSD 发展的多终末模型中一个可遗传途径的增加唤醒症状。
