微小 RNA 在肝脏疾病中的新作用。
Emerging role of microRNAs in liver diseases.
机构信息
Department of Medicine, University of Massachusetts Medical School, LRB 215, Worcester, MA 01605, USA.
出版信息
World J Gastroenterol. 2009 Dec 7;15(45):5633-40. doi: 10.3748/wjg.15.5633.
Abstract
MicroRNAs are a class of small non-coding RNAs that are found in plants, animals, and some viruses. They modulate the gene function at the post-transcriptional level and act as a fine tuner of various processes, such as development, proliferation, cell signaling, and apoptosis. They are associated with different types and stages of cancer. Recent studies have shown the involvement of microRNAs in liver diseases caused by various factors, such as Hepatitis C, Hepatitis B, metabolic disorders, and by drug abuse. This review highlights the role of microRNAs in liver diseases and their potential use as therapeutic molecules.
摘要
微小 RNA 是一类存在于植物、动物和一些病毒中的小型非编码 RNA。它们在转录后水平调节基因功能，作为各种过程的精细调节剂，如发育、增殖、细胞信号转导和细胞凋亡。它们与不同类型和阶段的癌症有关。最近的研究表明，微小 RNA 参与了由各种因素引起的肝脏疾病，如丙型肝炎、乙型肝炎、代谢紊乱和药物滥用。这篇综述强调了微小 RNA 在肝脏疾病中的作用及其作为治疗分子的潜在用途。
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