Arthritis Res Ther. 2009;11(5):129. doi: 10.1186/ar2818.
Infection is responsible for approximately 25% of all deaths in patients with systemic lupus erythematosus (SLE), making it a leading cause of mortality among patients. Ruiz-Irastorza and colleagues, in a recent issue of Arthritis Research & Therapy, report the clinical predictors of major infections found in a prospective study of patients with SLE. Similar patterns of infection and pathogens as reported in previous studies were seen; what is striking, however, was the protective effect seen with anti-malarial use. Many infections in patients with SLE could be prevented with timely vaccinations, reducing exposure to contagious contacts, screening for latent infections, minimizing exposure to corticosteroids, targeted prophylaxis for high risk patients, and, unless contraindicated, anti-malarial therapy as standard of care.
感染是导致系统性红斑狼疮（SLE）患者死亡的主要原因之一，约占所有死亡人数的 25%，这使其成为患者死亡的主要原因之一。在最近一期的《关节炎研究与治疗》杂志上，Ruiz-Irastorza 及其同事报告了 SLE 患者前瞻性研究中发现的主要感染的临床预测因素。研究中观察到的感染和病原体模式与之前的研究相似；然而，令人惊讶的是，抗疟药物的使用具有保护作用。通过及时接种疫苗、减少与传染性接触、筛查潜伏感染、尽量减少皮质类固醇暴露、对高危患者进行有针对性的预防、以及除非有禁忌症，将抗疟药物作为标准治疗，可以预防 SLE 患者的许多感染。
