Sleep Research and Treatment Center, Pennsylvania State University College of Medicine, Hershey, PA, USA.
J Clin Sleep Med. 2009 Jun 15;5(3):228-34.
Our objective was to examine the relationship between sleep disordered breathing (SDB) and neurocognitive functioning in a large general-population sample of children who underwent a full-night polysomnogram and comprehensive neuropsychological testing.
A population-based study of 571 school-aged children (6-12 years) underwent a 9-hour polysomnogram and a comprehensive neuropsychological battery.
No significant relationship was found between children with a mild apnea-hypopnea index (1 < or = apnea-hypopnea index < 5) and any measure of neuropsychological functioning (intelligence, verbal and nonverbal reasoning ability, attention, executive functioning, memory, processing speed, and visual-motor skill). Partial correlations between apnea-hypopnea index and neuropsychological test scores and polynominal trend analysis were all nonsignificant.
Children with mild SDB showed no significant neuropsychological impairment compared to children without SDB. This study suggests that children with mild SDB are not at risk for neuropsychological impairment and that the coexistence of mild SDB with any neuropsychological impairment should be considered comorbid and not causal. However, the association between neurobehavioral issues and children with mild SDB remains uncertain.
我们的目的是在一个经过整夜多导睡眠图和全面神经心理学测试的大型普通人群儿童样本中，研究睡眠呼吸障碍（SDB）与神经认知功能之间的关系。
对 571 名学龄儿童（6-12 岁）进行了 9 小时多导睡眠图和全面神经心理学测试。
在轻度呼吸暂停低通气指数（1 < = 呼吸暂停低通气指数 < 5）的儿童中，与任何神经心理学功能（智力、言语和非言语推理能力、注意力、执行功能、记忆、处理速度和视觉运动技能）之间未发现显著关系。呼吸暂停低通气指数与神经心理学测试分数之间的偏相关和多项式趋势分析均无显著意义。
与无 SDB 的儿童相比，轻度 SDB 的儿童没有明显的神经心理学损伤。本研究表明，轻度 SDB 的儿童没有神经认知功能受损的风险，并且轻度 SDB 与任何神经认知功能受损并存应被视为共病而不是因果关系。然而，神经行为问题与轻度 SDB 儿童之间的关联仍然不确定。
