Princeton University, Princeton, New Jersey, USA.
Emerg Infect Dis. 2009 Dec;15(12):1925-30. doi: 10.3201/eid1512.081341.
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has become a major problem in US hospitals already dealing with high levels of hospital-associated MRSA (HA-MRSA). Using antimicrobial drug susceptibility data for 1999-2006 from The Surveillance Network, we characterized the relationship between outpatient and inpatient levels of CA-MRSA nationally. In outpatients, the frequency of CA-MRSA isolates has increased >7 x during 1999-2006, which suggests that outpatients have become a major reservoir for CA-MRSA. However, contrary to results in other reports, although CA-MRSA increases are associated with decreases in the frequency of HA-MRSA in hospitals, the decreases are only modest. This finding suggests that instead of replacing HA-MRSA in the hospital, CA-MRSA is adding to the overall presence of MRSA already found within the hospital population.
社区获得性耐甲氧西林金黄色葡萄球菌（CA-MRSA）在美国医院中已经成为一个主要问题，这些医院已经面临高水平的医院获得性耐甲氧西林金黄色葡萄球菌（HA-MRSA）。利用来自监测网络的 1999-2006 年的抗菌药物药敏数据，我们描述了全国范围内门诊和住院患者 CA-MRSA 水平之间的关系。在门诊患者中，1999-2006 年期间 CA-MRSA 分离株的频率增加了>7 倍，这表明门诊患者已成为 CA-MRSA 的主要储主。然而，与其他报告的结果相反，尽管 CA-MRSA 的增加与医院中 HA-MRSA 频率的降低相关，但降低幅度仅适度。这一发现表明，CA-MRSA 的增加并没有取代医院中的 HA-MRSA，而是增加了医院人群中已经存在的 MRSA 的整体存在。
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