Davis Meghan F, Misic Ana M, Morris Daniel O, Moss John T, Tolomeo Pam, Beiting Daniel P, Nachamkin Irving, Lautenbach Ebbing, Rankin Shelley C
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA.
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey St., Philadelphia, Pennsylvania 19104, USA.
Vet Microbiol. 2015 Nov 18;180(3-4):304-7. doi: 10.1016/j.vetmic.2015.09.007. Epub 2015 Sep 24.
The strain dynamics of methicillin-resistant Staphylococcus aureus (MRSA) isolates from people and the household dog were investigated. The isolates were identified in the context of a randomized controlled trial that tested household-wide decolonization of people. Genotypic comparison of MRSA isolates obtained from two household members, the dog, and home surfaces over a three-month period failed to implicate the pet or the home environment in recurrent colonization of the household members. However, it did implicate the pet's bed in exposure of the dog prior to the dog's infection. Whole genome sequencing was performed to differentiate the isolates. This report also describes introduction of diverse strains of MRSA into the household within six weeks of cessation of harmonized decolonization treatment of people and treatment for infection in the dog. These findings suggest that community sources outside the home may be important for recurrent MRSA colonization or infection.
对来自人类和家犬的耐甲氧西林金黄色葡萄球菌（MRSA）分离株的菌株动态进行了研究。这些分离株是在一项测试全家庭人类去定植的随机对照试验背景下鉴定出来的。在三个月的时间里，对从两名家庭成员、家犬和家庭表面获得的MRSA分离株进行基因分型比较，结果表明宠物或家庭环境与家庭成员的反复定植无关。然而，这确实表明宠物床在犬感染之前使犬暴露于MRSA。通过全基因组测序对分离株进行区分。本报告还描述了在人类统一去定植治疗和犬感染治疗停止六周内，多种MRSA菌株引入家庭的情况。这些发现表明，家庭外部的社区来源可能对MRSA的反复定植或感染很重要。
