Ren Junyu, Da Junlong, Wu Wei, Zheng Ce, Hu Narisu
Oral Implant Center, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Institute of Hard Tissue Development and Regeneration, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Front Bioeng Biotechnol. 2022 Nov 30;10:934981. doi: 10.3389/fbioe.2022.934981. eCollection 2022.
Bacterial infections of the wounds on the skin surface significantly reduce the rate of wound healing, potentially leading to serious systemic infections. Antibiotics are the first-line drugs for the treatment of these infections. However, the misuse and overuse of antibiotics have led to the emergence of bacterial resistance. Therefore, a new antimicrobial strategy is urgently needed. Photothermal therapy (PTT) is a novel efficient therapeutic technique that can produce irreversible cell damage to induce death of bacteria, possessing a great potential in infected wound healing. This work describes the use of a new photothermal agent (PTA) such as niobium carbide (NbC) nanoparticles with outstanding near-infrared (NIR) absorption property. NbC nanoparticles converted NIR laser irradiation energy into localized heat for photothermal treatment. antimicrobial experiments have revealed that NbC nanoparticles exert excellent antimicrobial effects against () and (). Moreover, NbC nanoparticles accelerated -infected wound healing process, reduced inflammatory response, and showed good biosafety . Altogether, NbC nanoparticles represent an efficient PTA for antimicrobial treatment and are a bio-safe material with low toxicity .
皮肤表面伤口的细菌感染会显著降低伤口愈合速度，有可能导致严重的全身感染。抗生素是治疗这些感染的一线药物。然而，抗生素的滥用和过度使用导致了细菌耐药性的出现。因此，迫切需要一种新的抗菌策略。光热疗法（PTT）是一种新型高效的治疗技术，它可以对细胞产生不可逆的损伤以诱导细菌死亡，在感染伤口愈合方面具有巨大潜力。这项工作描述了一种新型光热剂（PTA）的应用，例如具有出色近红外（NIR）吸收特性的碳化铌（NbC）纳米颗粒。NbC纳米颗粒将近红外激光辐射能转化为局部热量用于光热治疗。抗菌实验表明，NbC纳米颗粒对（）和（）具有优异的抗菌效果。此外，NbC纳米颗粒加速了（）感染伤口的愈合过程，减轻了炎症反应，并显示出良好的生物安全性。总之，NbC纳米颗粒是一种用于抗菌治疗的高效光热剂，是一种低毒的生物安全材料。
