Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway.
Curr Opin Cell Biol. 2010 Apr;22(2):192-8. doi: 10.1016/j.ceb.2009.11.002. Epub 2009 Dec 2.
The two main protein degradation systems of eukaryotic cells, the ubiquitin-proteasome system and autophagy, have been thought of as quite separate systems. However, recent findings strongly suggest that there is crosstalk and even cooperation between these two degradation pathways. Ubiquitination and degradation of misfolded proteins by the ubiquitin-proteasome system have been investigated for some time, but much less is known about autophagic degradation of misfolded proteins. We will here discuss recent findings that shed some light on the cellular processes deciding when and how misfolded proteins are specifically selected for autophagic degradation in favor of proteasomal degradation.
真核细胞中的两种主要蛋白质降解系统，泛素-蛋白酶体系统和自噬，一直被认为是相当独立的系统。然而，最近的发现强烈表明这两种降解途径之间存在串扰，甚至存在合作。泛素化和蛋白酶体系统对错误折叠蛋白质的降解已经研究了一段时间，但对自噬性降解错误折叠蛋白质的了解要少得多。我们将在这里讨论最近的发现，这些发现揭示了一些细胞过程，这些过程决定了何时以及如何特异性选择错误折叠的蛋白质进行自噬性降解，而不是进行蛋白酶体降解。
