慢性硼暴露与人类精液参数。

Chronic boron exposure and human semen parameters.

机构信息

Center for Occupational and Environmental Health, University of California, Los Angeles, Los Angeles, CA 90095-6919, USA.

出版信息

Reprod Toxicol. 2010 Apr;29(2):184-90. doi: 10.1016/j.reprotox.2009.11.003. Epub 2009 Dec 3.

DOI:10.1016/j.reprotox.2009.11.003

PMID:19962437

Abstract

Boron found as borates in soil, food, and water has important industrial and medical applications. A panel reviewing NTP reproductive toxicants identified boric acid as high priority for occupational studies to determine safe versus adverse reproductive effects. To address this, we collected boron exposure/dose measures in workplace inhalable dust, dietary food/fluids, blood, semen, and urine from boron workers and two comparison worker groups (n=192) over three months and determined correlations between boron and semen parameters (total sperm count, sperm concentration, motility, morphology, DNA breakage, apoptosis and aneuploidy). Blood boron averaged 499.2 ppb for boron workers, 96.1 and 47.9 ppb for workers from high and low environmental boron areas (p<0.0001). Boron concentrated in seminal fluid. No significant correlations were found between blood or urine boron and adverse semen parameters. Exposures did not reach those causing adverse effects published in animal toxicology work but exceeded those previously published for boron occupational groups.

摘要

硼在土壤、食物和水中以硼酸盐的形式存在，具有重要的工业和医疗应用。一个审查 NTP 生殖毒物的小组将硼酸确定为职业研究的高优先级，以确定安全与不良生殖效应。为此，我们收集了硼工人和两个对照组工人（n=192）在三个月内的工作场所可吸入粉尘、饮食食物/液体、血液、精液和尿液中的硼暴露/剂量测量值，并确定了硼与精液参数（总精子数、精子浓度、活力、形态、DNA 断裂、凋亡和非整倍体）之间的相关性。硼工人的血液硼平均值为 499.2 ppb，高环境硼地区和低环境硼地区工人的血液硼平均值分别为 96.1 和 47.9 ppb（p<0.0001）。硼集中在精液中。血液或尿液中的硼与不良精液参数之间没有发现显著相关性。暴露量没有达到动物毒理学工作中公布的引起不良反应的水平，但超过了以前公布的硼职业群体的暴露量。