鞭毛内运输：它不再仅仅是为纤毛服务。
Intraflagellar transport: it's not just for cilia anymore.
机构信息
Department of Molecular, Cellular and Developmental Biology, 310 Kline Biology Tower, PO Box 208103, Yale University, New Haven, CT 06520-8103, United States.
出版信息
Curr Opin Cell Biol. 2010 Feb;22(1):75-80. doi: 10.1016/j.ceb.2009.10.010. Epub 2009 Dec 3.
Abstract
Recently published information on the role of intraflagellar transport (IFT) polypeptides in vesicle exocytosis is reviewed, describing the formation of the immune synapse in nonciliated cells as an example. A hypothesis is detailed suggesting that all polypeptides which enter the cilium, both membrane and axonemal, do so in association, first, with cytoplasmic vesicles which exocytose adjacent to the ciliary basal body, and then with the ciliary membrane. Axonemal proteins are moved to the ciliary tip by peripheral association with the inner aspects of the ciliary membrane by cannonical ciliary IFT. At the tip, some polypeptides are released for axonemal assembly, and others are budded off as part of vesicular exosomes into the environment. It is proposed that the cilium, in addition to being a sensory and motile organelle, is also a secretory organelle.
摘要
最近发表的关于鞭毛内运输（IFT）多肽在囊泡胞吐作用中的作用的信息进行了综述，以非纤毛细胞中免疫突触的形成为例。详细阐述了一个假说，即所有进入纤毛的多肽，无论是膜蛋白还是轴丝蛋白，首先与细胞质囊泡结合，这些囊泡在靠近纤毛基体的地方胞吐，然后与纤毛膜结合。轴丝蛋白通过与纤毛膜内侧面的经典鞭毛 IFT 进行外周结合，被运送到纤毛尖端。一些多肽在尖端释放用于轴丝组装，而另一些则作为囊泡外泌体的一部分脱落到环境中。提出纤毛除了作为感觉和运动细胞器之外，还是一种分泌细胞器。
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