一把双刃剑：NKT 细胞在疟疾和 HIV 感染及免疫中的作用。
A double-edged sword: the role of NKT cells in malaria and HIV infection and immunity.
机构信息
Aaron Diamond AIDS Research Center, New York, NY 10016, United States.
出版信息
Semin Immunol. 2010 Apr;22(2):87-96. doi: 10.1016/j.smim.2009.11.001. Epub 2009 Dec 4.
Abstract
NKT cells are known to play a role against certain microbial infections, including malaria and HIV, two major global infectious diseases. NKT cells exhibit either protective or pathogenic role against malaria. They are depleted by HIV infection and have a direct pathogenic role against many opportunistic infections common in end-stage AIDS. This review discusses the various features of the interaction between NKT cells and malaria parasites and HIV, and the potential to harness this interaction for therapeutic and vaccine strategies.
摘要
自然杀伤 T（NKT）细胞被认为在某些微生物感染中发挥作用，包括疟疾和艾滋病病毒（HIV），这两种疾病是全球主要的传染病。NKT 细胞在疟疾中表现出保护或致病作用。它们被 HIV 感染消耗，并对艾滋病晚期常见的许多机会性感染具有直接的致病作用。本文讨论了 NKT 细胞与疟原虫和 HIV 相互作用的各种特征，以及利用这种相互作用制定治疗和疫苗策略的潜力。
相似文献
1
A double-edged sword: the role of NKT cells in malaria and HIV infection and immunity.一把双刃剑：NKT 细胞在疟疾和 HIV 感染及免疫中的作用。
Semin Immunol. 2010 Apr;22(2):87-96. doi: 10.1016/j.smim.2009.11.001. Epub 2009 Dec 4.
2
Clinical development of a novel CD1d-binding NKT cell ligand as a vaccine adjuvant.新型 CD1d 结合型 NKT 细胞配体作为疫苗佐剂的临床开发。
Clin Immunol. 2011 Aug;140(2):142-51. doi: 10.1016/j.clim.2010.11.009. Epub 2010 Dec 24.
3
The role of invariant NKT cells at the interface of innate and adaptive immunity.天然免疫与适应性免疫交界中不变自然杀伤T细胞的作用。
Semin Immunol. 2010 Apr;22(2):59-60. doi: 10.1016/j.smim.2010.01.002. Epub 2010 Feb 20.
4
CD1d-Restricted Natural Killer T Cells Are Preserved in Indian Long-Term Nonprogressors.CD1d 限制性自然杀伤 T 细胞在印度长期不进展者中得以保留。
J Acquir Immune Defic Syndr. 2017 Aug 1;75(4):e104-e112. doi: 10.1097/QAI.0000000000001322.
5
NKT-cell glycolipid agonist as adjuvant in synthetic vaccine.NKT细胞糖脂激动剂作为合成疫苗中的佐剂。
Carbohydr Res. 2017 Nov 27;452:78-90. doi: 10.1016/j.carres.2017.10.006. Epub 2017 Oct 17.
6
Severe functional impairment and elevated PD-1 expression in CD1d-restricted NKT cells retained during chronic HIV-1 infection.在慢性HIV-1感染期间，CD1d限制性NKT细胞中存在严重的功能障碍和PD-1表达升高。
Eur J Immunol. 2009 Mar;39(3):902-11. doi: 10.1002/eji.200838780.
7
Interview: glycolipid antigen presentation by CD1d and the therapeutic potential of NKT cell activation.访谈：CD1d介导的糖脂抗原呈递及NKT细胞激活的治疗潜力
J Vis Exp. 2007(10):635. doi: 10.3791/635. Epub 2007 Dec 31.
8
NK cells and CD1d-restricted NKT cells respond in different ways with divergent kinetics to IL-2 treatment in primary HIV-1 infection.自然杀伤细胞和 CD1d 限制性 NKT 细胞对 IL-2 治疗原发性 HIV-1 感染的反应方式不同，动力学也不同。
Scand J Immunol. 2011 Feb;73(2):141-6. doi: 10.1111/j.1365-3083.2010.02484.x.
9
Functions of CD1d-Restricted Invariant Natural Killer T Cells in Antimicrobial Immunity and Potential Applications for Infection Control.CD1d 限制性不变自然杀伤 T 细胞在抗菌免疫中的功能及其在感染控制中的潜在应用。
Front Immunol. 2018 Jun 6;9:1266. doi: 10.3389/fimmu.2018.01266. eCollection 2018.
10
Complex Network of NKT Cell Subsets Controls Immune Homeostasis in Liver and Gut.NKT 细胞亚群的复杂网络控制肝脏和肠道中的免疫稳态。
Front Immunol. 2018 Sep 11;9:2082. doi: 10.3389/fimmu.2018.02082. eCollection 2018.
引用本文的文献
1
Five decades of clinical assessment of whole-sporozoite malaria vaccines.半个世纪以来对全孢子疟疾疫苗的临床评估。
Front Immunol. 2022 Sep 8;13:977472. doi: 10.3389/fimmu.2022.977472. eCollection 2022.
2
Functional Invariant Natural Killer T Cells Secreting Cytokines Are Associated With Non-Progressive Human Immunodeficiency Virus-1 Infection but Not With Suppressive Anti-Retroviral Treatment.功能性不变自然杀伤 T 细胞分泌细胞因子与非进展性人类免疫缺陷病毒 1 感染相关，但与抑制性抗逆转录病毒治疗无关。
Front Immunol. 2018 May 24;9:1152. doi: 10.3389/fimmu.2018.01152. eCollection 2018.
3
CD3CD4CD8 (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis.CD3CD4CD8（双阴性）T淋巴细胞和自然杀伤T细胞，作为巴西利什曼原虫（维扬亚利什曼原虫）引起的皮肤利什曼病病变中主要的与细胞毒性相关的CD107a细胞。
Parasit Vectors. 2017 May 3;10(1):219. doi: 10.1186/s13071-017-2152-2.
4
Ex-vivo analysis of human natural killer T cells demonstrates heterogeneity between tissues and within established CD4(+) and CD4(-) subsets.对人自然杀伤 T 细胞的离体分析表明，组织之间以及已建立的 CD4(+)和 CD4(-)亚群内存在异质性。
Clin Exp Immunol. 2013 Apr;172(1):129-37. doi: 10.1111/cei.12045.
5
Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions.不变自然杀伤 T 细胞：与多种效应功能相关的先天激活方案。
Nat Rev Immunol. 2013 Feb;13(2):101-17. doi: 10.1038/nri3369. Epub 2013 Jan 21.
6
NK cells and CD1d-restricted NKT cells respond in different ways with divergent kinetics to IL-2 treatment in primary HIV-1 infection.自然杀伤细胞和 CD1d 限制性 NKT 细胞对 IL-2 治疗原发性 HIV-1 感染的反应方式不同，动力学也不同。
Scand J Immunol. 2011 Feb;73(2):141-6. doi: 10.1111/j.1365-3083.2010.02484.x.
7
Clinical development of a novel CD1d-binding NKT cell ligand as a vaccine adjuvant.新型 CD1d 结合型 NKT 细胞配体作为疫苗佐剂的临床开发。
Clin Immunol. 2011 Aug;140(2):142-51. doi: 10.1016/j.clim.2010.11.009. Epub 2010 Dec 24.
8
Anti-tumor potential of type-I NKT cells against CD1d-positive and CD1d-negative tumors in humans.I 型 NKT 细胞对人类 CD1d 阳性和 CD1d 阴性肿瘤的抗肿瘤潜力。
Clin Immunol. 2011 Aug;140(2):119-29. doi: 10.1016/j.clim.2010.10.005. Epub 2010 Nov 20.
9
Impairment of CD1d-restricted natural killer T cells in chronic HIV type 1 clade C infection.慢性1型C亚型HIV感染中CD1d限制性自然杀伤T细胞的损伤
AIDS Res Hum Retroviruses. 2011 May;27(5):501-9. doi: 10.1089/AID.2010.0237. Epub 2010 Dec 13.
本文引用的文献
1
Invariant TCR rather than CD1d shapes the preferential activities of C-glycoside analogues against human versus murine invariant NKT cells.不变T细胞受体而非CD1d决定了C-糖苷类似物对人源与鼠源不变自然杀伤T细胞的优先活性。
J Immunol. 2009 Oct 1;183(7):4415-21. doi: 10.4049/jimmunol.0901021. Epub 2009 Sep 4.
2
Incorporation of NKT cell-activating glycolipids enhances immunogenicity and vaccine efficacy of Mycobacterium bovis bacillus Calmette-Guerin.纳入NKT细胞激活糖脂可增强卡介苗的免疫原性和疫苗效力。
J Immunol. 2009 Aug 1;183(3):1644-56. doi: 10.4049/jimmunol.0900858.
3
Lower cytokine secretion ex vivo by natural killer T cells in HIV-infected individuals is associated with higher CD161 expression.HIV 感染者体内自然杀伤 T 细胞的细胞因子分泌减少与 CD161 表达升高有关。
AIDS. 2009 Sep 24;23(15):1965-70. doi: 10.1097/QAD.0b013e32832b5134.
4
Alpha-C-galactosylceramide as an adjuvant for a live attenuated influenza virus vaccine.α - 半乳糖神经酰胺作为减毒活流感病毒疫苗的佐剂
Vaccine. 2009 Jun 8;27(28):3766-74. doi: 10.1016/j.vaccine.2009.03.090. Epub 2009 Apr 23.
5
The mucosal adjuvant effect of alpha-galactosylceramide for induction of protective immunity to sexually transmitted viral infection.α-半乳糖神经酰胺对诱导针对性传播病毒感染的保护性免疫的黏膜佐剂作用。
J Immunol. 2009 May 15;182(10):6435-43. doi: 10.4049/jimmunol.0900136.
6
CD1d activation and blockade: a new antitumor strategy.CD1d激活与阻断：一种新的抗肿瘤策略。
J Immunol. 2009 Mar 15;182(6):3366-71. doi: 10.4049/jimmunol.0802964.
7
A phase I-II study of alpha-galactosylceramide-pulsed IL-2/GM-CSF-cultured peripheral blood mononuclear cells in patients with advanced and recurrent non-small cell lung cancer.α-半乳糖神经酰胺脉冲处理的白细胞介素-2/粒细胞-巨噬细胞集落刺激因子培养的外周血单个核细胞用于晚期和复发性非小细胞肺癌患者的I-II期研究。
J Immunol. 2009 Feb 15;182(4):2492-501. doi: 10.4049/jimmunol.0800126.
8
Alpha-galactosylceramide is an effective mucosal adjuvant for repeated intranasal or oral delivery of HIV peptide antigens.α-半乳糖神经酰胺是一种有效的黏膜佐剂，可用于经鼻或口服重复递送HIV肽抗原。
Vaccine. 2009 May 26;27(25-26):3335-41. doi: 10.1016/j.vaccine.2009.01.083. Epub 2009 Feb 5.
9
Natural killer T cells and autoimmune disease.自然杀伤性T细胞与自身免疫性疾病。
Curr Mol Med. 2009 Feb;9(1):4-14. doi: 10.2174/156652409787314534.
10
Severe functional impairment and elevated PD-1 expression in CD1d-restricted NKT cells retained during chronic HIV-1 infection.在慢性HIV-1感染期间，CD1d限制性NKT细胞中存在严重的功能障碍和PD-1表达升高。
Eur J Immunol. 2009 Mar;39(3):902-11. doi: 10.1002/eji.200838780.
Zotero 插件