Aaron Diamond AIDS Research Center, New York, NY 10016, United States.
Semin Immunol. 2010 Apr;22(2):87-96. doi: 10.1016/j.smim.2009.11.001. Epub 2009 Dec 4.
NKT cells are known to play a role against certain microbial infections, including malaria and HIV, two major global infectious diseases. NKT cells exhibit either protective or pathogenic role against malaria. They are depleted by HIV infection and have a direct pathogenic role against many opportunistic infections common in end-stage AIDS. This review discusses the various features of the interaction between NKT cells and malaria parasites and HIV, and the potential to harness this interaction for therapeutic and vaccine strategies.
自然杀伤 T(NKT)细胞被认为在某些微生物感染中发挥作用,包括疟疾和艾滋病病毒(HIV),这两种疾病是全球主要的传染病。NKT 细胞在疟疾中表现出保护或致病作用。它们被 HIV 感染消耗,并对艾滋病晚期常见的许多机会性感染具有直接的致病作用。本文讨论了 NKT 细胞与疟原虫和 HIV 相互作用的各种特征,以及利用这种相互作用制定治疗和疫苗策略的潜力。