Wei Bing-Bing, Xi Bo, Wang Ruoqi, Bai Jin-Ming, Chang Jun-Kai, Zhang Yun-Yun, Yoneda Raegan, Su Jian-Tang, Hua Li-Xin
Department of Urology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China.
Cancer Genet Cytogenet. 2010 Jan 1;196(1):68-75. doi: 10.1016/j.cancergencyto.2009.09.016.
Transforming growth factor-beta1 (TGFbeta1) plays a significant role in regulating cellular proliferation and apoptosis. The TGFbeta1 T29C polymorphism reportedly affects cancer risk, but pertinent studies offer conflicting results. We therefore performed a meta-analysis based on 40 studies from 32 publications, assessing the strength of the association using odds ratios with 95% confidence intervals. Overall, no evidence has indicated that individuals carrying CC or CT genotypes had significantly increased cancer risks, compared with TT genotype carriers [CC vs. TT: odds ratio (OR)=1.10, 95% confidence interval (95% CI)=1.00-1.21, P=0.06; CT vs. TT: OR=1.07, 95% CI=0.99-1.16, P=0.09). However, stratified analysis by cancer type and ethnicity indicated a significantly increased risk of prostate cancer (CT vs. TT: OR=1.28, 95% CI=1.01-1.61, P=0.04) and cancer in those of Asian descent (CC vs. TT: OR=1.26, 95% CI=1.03-1.53, P=0.02; CT vs. TT: OR=1.20, 95% CI=1.01-1.43, P=0.04). This association was also observed in the dominant model for prostate cancer. Although not all bias could be eliminated, this meta-analysis suggested that TGFbeta1 29C was a low-penetrant risk factor for prostate cancer and cancer in Asians. A larger single study is still required to evaluate any association with other types of cancer or in other populations.
转化生长因子-β1（TGFβ1）在调节细胞增殖和凋亡中起重要作用。据报道，TGFβ1 T29C多态性会影响癌症风险，但相关研究结果相互矛盾。因此，我们基于32篇出版物中的40项研究进行了一项荟萃分析，使用比值比及95%置信区间评估关联强度。总体而言，没有证据表明携带CC或CT基因型的个体与携带TT基因型的个体相比，癌症风险显著增加[CC与TT相比：比值比（OR）=1.10，95%置信区间（95%CI）=1.00 - 1.21，P = 0.06；CT与TT相比：OR = 1.07，95%CI = 0.99 - 1.16，P = 0.09]。然而，按癌症类型和种族进行的分层分析表明，前列腺癌风险显著增加（CT与TT相比：OR = 1.28，95%CI = 1.01 - 1.61，P = 0.04），亚洲血统人群患癌风险增加（CC与TT相比：OR = 1.26，95%CI = 1.03 - 1.53，P = 0.02；CT与TT相比：OR = 1.20，95%CI = 1.01 - 1.43，P = 0.04）。在前列腺癌的显性模型中也观察到了这种关联。尽管不能消除所有偏倚，但这项荟萃分析表明，TGFβ1 29C是前列腺癌和亚洲人患癌的低外显率风险因素。仍需要更大规模的单一研究来评估与其他类型癌症或其他人群的任何关联。
