Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Cytokine. 2011 Dec;56(3):589-92. doi: 10.1016/j.cyto.2011.08.019. Epub 2011 Sep 9.
Published data on the association between miR-196a2 T/C polymorphism and cancer susceptibility are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 21 studies including 10,441 cases and 12,353 controls were involved in this meta-analysis. Overall, significantly elevated cancer risk was associated with miR-196a2 C allele when all studies were pooled into the meta-analysis (TC vs. TT: OR=1.23, 95% CI=1.11-1.36; CC vs. TT: OR=1.30, 95% CI=1.14-1.48; dominant model: OR=1.25, 95% CI=1.13-1.38). In the subgroup analysis by ethnicity, significantly increased risks were found in Asains (TC vs. TT: OR=1.24, 95% CI=1.10-1.40; CC vs. TT: OR=1.31, 95% CI=1.13-1.52; dominant model: OR=1.26, 95% CI=1.12-1.41) but with bordline statistical significance in Caucasians (TC vs. TT: OR=1.15, 95% CI=1.00-1.31). In the subgroup analysis by cancer type, statistically significantly increased risks were found for breast cancer (TC vs. TT: OR=1.15, 95% CI=1.01-1.31; CC vs. TT: OR=1.30, 95% CI=1.01-1.68; dominant model: OR=1.22, 95% CI=1.00-1.50; and recessive model: OR=1.11, 95% CI=1.01-1.23) and lung cancer (CC vs. TT: OR=1.30, 95% CI=1.10-1.54; and recessive model: OR=1.18, 95% CI=1.02-1.36). When stratified by study design, statistically significantly elevated risk was found in hospital-based studies (TC vs. TT: OR=1.30, 95% CI=1.13-1.49; CC vs. TT: OR=1.37, 95% CI=1.14-1.66; dominant model: OR=1.32, 95% CI=1.15-1.53) and population-based studies (CC vs. TT: OR=1.19, 95% CI=1.06-1.35; dominant model: OR=1.13, 95% CI=1.01-1.25). Despite some limitations, this meta-analysis suggests that the miR-196a2 C allele is a low-penetrant risk factor for cancer development.
已发表的关于 miR-196a2 T/C 多态性与癌症易感性之间关联的研究结果并不一致。为了更精确地评估这种关系，我们进行了荟萃分析。该荟萃分析共纳入了 21 项研究，包括 10441 例病例和 12353 例对照。总体而言，当所有研究合并进行荟萃分析时，miR-196a2 C 等位基因与癌症风险显著升高相关（TC 与 TT：OR=1.23，95%CI=1.11-1.36；CC 与 TT：OR=1.30，95%CI=1.14-1.48；显性模型：OR=1.25，95%CI=1.13-1.38）。按种族亚组分析，在亚洲人群中发现了明显升高的风险（TC 与 TT：OR=1.24，95%CI=1.10-1.40；CC 与 TT：OR=1.31，95%CI=1.13-1.52；显性模型：OR=1.26，95%CI=1.12-1.41），但在高加索人群中具有边缘统计学意义（TC 与 TT：OR=1.15，95%CI=1.00-1.31）。按癌症类型的亚组分析，在乳腺癌（TC 与 TT：OR=1.15，95%CI=1.01-1.31；CC 与 TT：OR=1.30，95%CI=1.01-1.68；显性模型：OR=1.22，95%CI=1.00-1.50；隐性模型：OR=1.11，95%CI=1.01-1.23）和肺癌（CC 与 TT：OR=1.30，95%CI=1.10-1.54；隐性模型：OR=1.18，95%CI=1.02-1.36）中发现了统计学显著升高的风险。按研究设计分层，在基于医院的研究（TC 与 TT：OR=1.30，95%CI=1.13-1.49；CC 与 TT：OR=1.37，95%CI=1.14-1.66；显性模型：OR=1.32，95%CI=1.15-1.53）和基于人群的研究（CC 与 TT：OR=1.19，95%CI=1.06-1.35；显性模型：OR=1.13，95%CI=1.01-1.25）中发现了统计学显著升高的风险。尽管存在一些局限性，但这项荟萃分析表明，miR-196a2 C 等位基因是癌症发生的低外显度风险因素。
