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本文引用的文献

1
Reactivity of superoxide anion radical with a perchlorotriphenylmethyl (trityl) radical.超氧阴离子自由基与高氯代三苯甲基（三苯甲基）自由基的反应活性。
J Phys Chem B. 2008 Jan 10;112(1):158-67. doi: 10.1021/jp076656x. Epub 2007 Dec 15.
2
Synthesis and characterization of a perchlorotriphenylmethyl (trityl) triester radical: a potential sensor for superoxide and oxygen in biological systems.一种高氯代三苯甲基（三苯甲基）三酯自由基的合成与表征：生物系统中超氧化物和氧气的潜在传感器。
Bioorg Med Chem Lett. 2007 Jul 15;17(14):4062-5. doi: 10.1016/j.bmcl.2007.04.070. Epub 2007 Apr 27.
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Asymmetric allylic substitution catalyzed by C1-symmetrical complexes of molybdenum: structural requirements of the ligand and the stereochemical course of the reaction.钼的C1对称配合物催化的不对称烯丙基取代反应：配体的结构要求及反应的立体化学过程
Chemistry. 2006 Sep 6;12(26):6910-29. doi: 10.1002/chem.200501574.
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Reactive oxygen species: role in the development of cancer and various chronic conditions.活性氧物种：在癌症和各种慢性疾病发展中的作用。
J Carcinog. 2006 May 11;5:14. doi: 10.1186/1477-3163-5-14.
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Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide.线粒体超氧化物歧化酶模拟物抑制过氧化物诱导的氧化损伤和细胞凋亡：线粒体超氧化物的作用
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Reaction of superoxide with trityl radical: implications for the determination of superoxide by spectrophotometry.超氧化物与三苯甲基自由基的反应：对分光光度法测定超氧化物的意义。
Arch Biochem Biophys. 2004 Apr 1;424(1):81-8. doi: 10.1016/j.abb.2004.01.020.
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Application of a trityl-based radical probe for measuring superoxide.一种基于三苯甲基的自由基探针在超氧化物测量中的应用。
Free Radic Biol Med. 2003 Dec 15;35(12):1608-18. doi: 10.1016/j.freeradbiomed.2003.09.014.
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Oxidation of the perchlorotriphenylmethyl radical to the carbocation, and its unique abrupt reversion.
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Interaction of singlet molecular oxygen with double fluorescent and spin sensors.单重态分子氧与双荧光和自旋传感器的相互作用。
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Pyrene-neomycin conjugate: dual recognition of a DNA triple helix.芘-新霉素缀合物：对DNA三螺旋的双重识别
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高氯酸三苯甲基自由基-荧光团缀合物作为超氧阴离子自由基的双荧光和 EPR 探针。

Perchlorotrityl radical-fluorophore conjugates as dual fluorescence and EPR probes for superoxide radical anion.

机构信息

Davis Heart and Lung Research Institute, Department of Chemistry, The Ohio State University, Columbus, OH 43210, USA.

出版信息

Bioorg Med Chem. 2010 Jan 15;18(2):922-9. doi: 10.1016/j.bmc.2009.11.034. Epub 2009 Dec 4.

DOI:10.1016/j.bmc.2009.11.034
PMID:19963389
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2827402/
Abstract

Perchlorotrityl radicals, mono-substituted with a fluorophore using an amide linker of varying chain length, were synthesized and characterized. Electron paramagnetic resonance (EPR) spectroscopic study indicated free-electron coupling with the aromatic hydrogen nuclei and long-range coupling with the methylene hydrogens of the linker group. Reactivity of the fluorophore-conjugated trityls with superoxide radical anion showed quenching of EPR signal and enhancement of fluorescence emission spectrum. This work presents the first example of a perchlorotrityl-fluorophore conjugate that can potentially be employed as a dual probe for the detection of superoxide under oxidative stress-mediated conditions in biological systems.

摘要

全氯三苯甲基自由基经酰胺键连接不同链长的荧光团单取代后合成并进行了表征。电子顺磁共振（EPR）谱学研究表明，与芳氢核存在自由电子偶合，与连接基团的亚甲基氢存在远程偶合。与超氧自由基阴离子的反应表明，荧光团偶联的三苯甲基的 EPR 信号猝灭和荧光发射光谱增强。本工作首次报道了全氯三苯甲基-荧光团偶联物，该偶联物有望成为生物体系氧化应激条件下检测超氧的双重探针。