正常和衰竭心脏中兴奋-收缩偶联的多尺度建模
Multi-scale modeling of excitation-contraction coupling in the normal and failing heart.
作者信息
Kerckhoffs Roy C P, Campbell Stuart G, Flaim Sarah N, Howard Elliot J, Sierra-Aguado Jazmin, Mulligan L J, McCulloch Andrew D
机构信息
Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:4281-2. doi: 10.1109/IEMBS.2009.5332708.
Abstract
Here we describe new computational models of cardiac electromechanics starting from the cellular scale and building to the tissue, organ and system scales. We summarize application to human genetic diseases (LQT1 and LQT3) and to modeling of congestive heart failure.
摘要
在此，我们描述了从细胞尺度开始构建至组织、器官和系统尺度的心脏电机械学新计算模型。我们总结了其在人类遗传疾病（LQT1和LQT3）中的应用以及在充血性心力衰竭建模中的应用。
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