Guo Liang, Deweerth Stephen P
Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332 USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:1623-6. doi: 10.1109/IEMBS.2009.5333446.
A method for fabricating polydimethylsiloxane (PDMS) based conformable microelectrode arrays (MEAs) with selectable novel 3-D microelectrode geometries is presented. Simply recessed, conically recessed, exponentially recessed, and protruded-well microelectrodes have been fabricated on the MEA with a diameter as small as 10microm. 3-D microelectrode geometry parameters (recess depth, recess slope & profile, and protrusion/planar) can be controlled independently during fabrication. Exponentially and conically recessed microelectrodes are promising in chronic stimulation applications, such as neural prostheses, for their production of a uniform current density profile during stimulation, which can minimize stimulation-induced tissue burning and electrode corrosion. Protruded-well microelectrodes potentially provide a closer and sealed contact to the target tissue surface, avoiding current leakage during stimulation and thus achieving better stimulation efficiency in both charge delivery and spatial specificity.
本文提出了一种制造基于聚二甲基硅氧烷（PDMS）的可贴合微电极阵列（MEA）的方法，该阵列具有可选择的新型三维微电极几何形状。在直径小至10微米的MEA上制造了简单凹陷、锥形凹陷、指数凹陷和凸阱微电极。在制造过程中，可以独立控制三维微电极的几何参数（凹陷深度、凹陷斜率和轮廓以及凸起/平面度）。指数凹陷和锥形凹陷微电极在慢性刺激应用（如神经假体）中很有前景，因为它们在刺激过程中产生均匀的电流密度分布，这可以最大限度地减少刺激引起的组织灼伤和电极腐蚀。凸阱微电极可能与目标组织表面提供更紧密和密封的接触，避免刺激过程中的电流泄漏，从而在电荷传递和空间特异性方面实现更好的刺激效率。
