兔模型上的无创三维心脏激动成像

Noninvasive three-dimensional cardiac activation imaging on a rabbit model.

作者信息

Han Chengzong, Liu Chenguang, Pogwizd Steven, He Bin

机构信息

Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:3271-3. doi: 10.1109/IEMBS.2009.5333511.

DOI:10.1109/IEMBS.2009.5333511

PMID:19964067

Abstract

Three-dimensional cardiac activation imaging (3-DCAI) aims at imaging the activation sequence throughout the 3-D myocardium. In the present study, the performance of 3-DCAI was validated through both in vivo animal experiments and computer simulations under a pacing protocol. The non-invasively imaged activation sequence from body surface potential maps (BSPMs) was quantitatively compared with the measured activation sequence obtained from the simultaneous intramural recording using a 3-D intra-cardiac mapping technique in a rabbit model. In addition, computer simulations were conducted to provide further assessment of the performance of the 3-DCAI algorithm in a realistic-geometry rabbit heart-torso model. The encouraging results suggest that 3-DCAI can non-invasively image the activation sequence and localize the origin of activation with good accuracy.

摘要

三维心脏激动成像（3-DCAI）旨在对整个三维心肌的激动序列进行成像。在本研究中，通过体内动物实验和起搏方案下的计算机模拟对3-DCAI的性能进行了验证。将体表电位图（BSPM）无创成像得到的激动序列与在兔模型中使用三维心内标测技术同时进行心壁内记录获得的实测激动序列进行了定量比较。此外，还进行了计算机模拟，以在逼真几何形状的兔心-躯干模型中进一步评估3-DCAI算法的性能。令人鼓舞的结果表明，3-DCAI能够无创地成像激动序列并准确地定位激动起源。