Trayanova Natalia A
Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, 3400 North Charles Street, Hackerman Hall Room 216, Baltimore, MD 21218, USA.
ISRN Cardiol. 2012;2012:269680. doi: 10.5402/2012/269680. Epub 2012 Nov 14.
This paper reviews the newest developments in computational cardiology. It focuses on the contribution of cardiac modeling to the development of new therapies as well as the advancement of existing ones for cardiac arrhythmias and pump dysfunction. Reviewed are cardiac modeling efforts aimed at advancing and optimizing existent therapies for cardiac disease (defibrillation, ablation of ventricular tachycardia, and cardiac resynchronization therapy) and at suggesting novel treatments, including novel molecular targets, as well as efforts to use cardiac models in stratification of patients likely to benefit from a given therapy, and the use of models in diagnostic procedures.
本文综述了计算心脏病学的最新进展。它重点关注心脏建模对新疗法开发的贡献，以及对现有心律失常和泵功能障碍治疗方法的改进。回顾了旨在推进和优化现有心脏病治疗方法（除颤、室性心动过速消融和心脏再同步治疗）、提出新治疗方法（包括新的分子靶点）的心脏建模工作，以及利用心脏模型对可能从特定治疗中获益的患者进行分层的努力，还有模型在诊断程序中的应用。
