White Brian R, Snyder Abraham Z, Cohen Alexander L, Petersen Steven E, Raichle Marcus E, Schlaggar Bradley L, Culver Joseph P
Department of Physics, Washington University, St. Louis, MO, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:4070-2. doi: 10.1109/IEMBS.2009.5333199.
Diffuse optical tomography (DOT) is a portable functional neuroimaging technique that is able to simultaneously measure both oxy- and deoxyhemoglobin responses to brain activity. Herein, we demonstrate a technique for mapping functional connections in the brain by measuring the spatial distribution of temporal correlations in resting brain activity. Simultaneous DOT imaging over the motor and visual cortices yielded robust correlation maps reproducing the expected functional neural architecture. These functional connectivity methods will have utility in certain populations, such as those who are unconscious or very young, who have difficulty performing the behaviors required in traditional task-based functional neuroimaging paradigms.
扩散光学断层扫描（DOT）是一种便携式功能神经成像技术，能够同时测量氧合血红蛋白和脱氧血红蛋白对大脑活动的反应。在此，我们展示了一种通过测量静息脑活动中时间相关性的空间分布来绘制大脑功能连接的技术。在运动皮层和视觉皮层上同时进行DOT成像，产生了强大的相关图，再现了预期的功能性神经结构。这些功能连接方法将在某些人群中发挥作用，例如那些无意识或非常年幼的人群，他们难以执行传统基于任务的功能神经成像范式所需的行为。
